21:43 , Jul 12, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: June 2018

New Therapeutic Targets and Biomarkers: June 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during June 2018. Therapeutic targets are defined as any protein, gene or other molecule...
18:18 , Jun 13, 2018 |  BC Innovations  |  Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Hypercholesterolemia Patient sample and mouse studies suggest inhibiting LIMA1 could help treat hypercholesterolemia. Whole-genome sequencing of patient plasma samples identified an association between a rare frameshift variant of LIMA1 and low levels of LDL-C...
22:47 , Jun 7, 2018 |  BC Extra  |  Preclinical News

Inhibiting LIMA1 could treat hypercholesterolemia

A study published in Science from researchers at the Chinese Academy of Sciences suggested that inhibiting LIM domain and actin binding 1 (LIMA1; SREBP3) could reduce cholesterol absorption and help treat hypercholesterolemia. High levels of LDL-C...