BioCentury | Aug 30, 2019
Translation in Brief

DNA trumps protein in Huntington onset

Two independent studies from former Teva CSO Michael Hayden and a Boston-based consortium suggest long, uninterrupted stretches of DNA repeats -- not the amino acids they encode -- could be the key to predicting and...
BioCentury | Nov 29, 2018
Translation in Brief

Beyond BRCA

...homologous recombination or non-homologous end joining, including BRCA2, x-ray repair cross complementing 4 (XRCC4) and DNA ligase 4 (LIG4)...
BioCentury | Jul 24, 2018
Distillery Techniques

Assays and screens

TECHNOLOGY: Binding assays; cellular assays A screening method using non-coding SNPs from genome-wide association studies (GWAS) could help identify new drug targets. The method involves five steps: creating double-stranded 31-base pair DNA constructs with each...
BioCentury | Dec 8, 2017
Targets & Mechanisms

Pathways emerging from ASH

...general anticancer mechanism. OGG1 is an enzyme used to repair bases damaged by oxidative stress, LIG4...
...Fcγ receptor IIb GP-9 (CD42a) - Glycoprotein-9 IRF7 - Interferon regulatory factor 7 LIG4 - DNA ligase 4...
...HMMH) BRCA1-associated protein 1 (BAP1) Bromodomain testis-specific (BRDT) CC chemokine receptor 2 (CCR2) (CD192) DEAD box polypeptide 58 (RIG-I) (DDX58) DNA ligase 4 (LIG4) DNA...
BioCentury | Dec 8, 2017
Targets & Mechanisms

Epiphenomena at ASH

...chemokine receptor 2 (CCR2; CD192) 4 0 CD1D 6 0 Cyclin A2 (CCNA2) 4 0 DNA ligase 4 (LIG4)...
BioCentury | Apr 7, 2016
Translation in Brief

Knowing when to fold

A team from the Flanders Institute for Biotechnology (VIB) has linked two genes involved in the unfolded protein stress response to the fragility of pancreatic β cells involved in both Type I and Type II...
BioCentury | Jan 27, 2011
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Bacterial infection DNA ligase, NAD+-dependent (LigA) In vitro and mouse studies identified inhibitors of the bacterial enzyme LigA that could help treat bacterial infections....
BioCentury | Apr 22, 2010
Distillery Therapeutics

Indication: Cancer

...Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer Ligase IV, DNA, ATP-dependent (LIG4...
...telomere elongation helicase 1 (RTEL1); coiled-coil domain containing 26 (CCDC26) Genetic association studies suggest that LIG4...
...BTBD2, HMGA2 and RTEL1 polymorphisms could help predict survival in glioblastoma. In subjects with glioblastoma, LIG4...
BioCentury | Apr 23, 2009
Tools & Techniques

DNA assembly: simple and super-sized

Researchers at the J. Craig Venter Institute have developed an in vitro method for assembling DNA fragments into molecules several hundred kilobases long in a quick, one-step reaction. 1 The method should make the construction...
BioCentury | Nov 13, 2008
Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Trypanosomiasis RNA-editing ligase 1 (REL1) Virtual screening and in vitro studies identified inhibitors of the trypanosome enzyme REL1 that might...
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