BioCentury | Aug 11, 2018
Product Development

Exacerbation management

...year end, is to measure pulmonary exacerbation as the primary endpoint. Acebilustat is a leukotriene A4 hydrolase (LTA4H...
...CTX-4430, ep-501) Lenabasum (JBT-101, anabasum, resunab) Celtaxsys Inc. Corbus Pharmaceuticals Holdings Inc. Cystic Fibrosis Foundation Cannabinoid receptor 2 (CB2) (CNR2) Leukotriene A4 hydrolase (LTA4H) CF...
BioCentury | Aug 3, 2018
Clinical News

Celtaxsys planning Phase III program for CF candidate

...from the Phase II EMPIRE-CF trial of the candidate in the indication. While the leukotriene A4 hydrolase (LTA4H...
...Celtaxsys Inc., Atlanta, Ga. Product: Acebilustat (CTX-4430) Business: Pulmonary Molecular target: Leukotriene A4 hydrolase (LTA4H) Description: LTA4H...
...and biomarkers Status: Phase II data Milestone: Start Phase III (2H19) Jennie Walters Acebilustat (CTX-4430, ep-501) Celtaxsys Inc. Leukotriene A4 hydrolase (LTA4H...
BioCentury | Aug 2, 2018
Clinical News

Celtaxsys planning Phase III program for CF candidate

...from the Phase II EMPIRE-CF trial of the candidate in the indication. While the leukotriene A4 hydrolase (LTA4H...
...requiring treatment with IV antibiotics vs. placebo (see “Foundation Validation” ). Jennie Walters Acebilustat (CTX-4430, ep-501) Celtaxsys Inc. Leukotriene A4 hydrolase (LTA4H) North...
BioCentury | Jan 19, 2018
Clinical News

Eiger discontinues ubenimex for PAH

...II LIBERTY trial in the indication. Eiger will continue development of the small molecule leukotriene A4 hydrolase (LTA4H...
...Bestatin ubenimex Business: Cardiovascular Molecular target: Leukotriene A4 hydrolase (LTA4H); Arginyl aminopeptidase (RNPEP; AP-B) Description: Small molecule LTA4H...
...Status: Development discontinued Milestone: NA Jaime De Leon Bestatin ubenimex Eiger BioPharmaceuticals Inc. Nippon Kayaku Co. Ltd. Arginyl aminopeptidase (RNPEP) (AP-B) Leukotriene A4 hydrolase (LTA4H) Leukotriene...
BioCentury | Jan 16, 2018
Clinical News

Phase II PAH readout sinks Eiger shares

...II LIBERTY trial in the indication. Eiger will continue development of the small molecule leukotriene A4 hydrolase (LTA4H...
...agents for acute non-lymphocytic leukemia. Jaime De Leon Bestatin ubenimex Eiger BioPharmaceuticals Inc. Nippon Kayaku Co. Ltd. Arginyl aminopeptidase (RNPEP) (AP-B) Leukotriene A4 hydrolase (LTA4H...
BioCentury | May 19, 2017
Clinical News

Eiger completes enrollment in Phase II to treat PAH

...enroll in the open-label LIBERTY2 extension study. Bestatin is a small molecule inhibitor of leukotriene A4 hydrolase (LTA4H...
...Cardiovascular Molecular target: Leukotriene A4 hydrolase (LTA4H) ; Arginyl aminopeptidase ( RNPEP ; AP-B) Description: Small molecule LTA4H...
...enrollment Milestone: Phase II data (1Q18) Julian Zhu Bestatin ubenimex Eiger BioPharmaceuticals Inc. Nippon Kayaku Co. Ltd. Arginyl aminopeptidase (RNPEP) (AP-B) Leukotriene A4 hydrolase (LTA4H...
BioCentury | Feb 1, 2017
Clinical News

Bestatin: LIBERTY2 extension study started

...Cardiovascular Molecular target: Leukotriene A4 hydrolase (LTA4H) ; Arginyl aminopeptidase ( RNPEP ; AP-B) Description: Small molecule LTA4H...
...Milestone: Complete Phase II enrollment (mid-2017) Chris Lieu Bestatin ubenimex Eiger BioPharmaceuticals Inc. Nippon Kayaku Co. Ltd. Arginyl aminopeptidase (RNPEP) (AP-B) Leukotriene A4 hydrolase (LTA4H...
BioCentury | Sep 1, 2016
Distillery Therapeutics

Therapeutics: Lipoteichoic acid (LTA); heparin-binding EGF-like growth factor (HBEGF; DTR)

Infectious disease INDICATION: Clostridium Mouse studies suggest LTA glycan-based vaccines could help prevent Clostridium difficile infection (CDI). In a mouse challenge model of CDI, a compound composed of glycans from C. difficile LTA conjugated to...
BioCentury | Aug 8, 2016
Clinical News

Bestatin ubenimex: Phase II started

...Tokyo, Japan Product: Bestatin ubenimex Business: Inflammation Molecular target: Leukotriene A4 hydrolase (LTA4H) Description: Small molecule leukotriene A4 hydrolase (LTA4H...
BioCentury | Dec 14, 2015
Company News

Nippon Kayaku, Eiger deal

...to chemotherapy agents for non-lymphocytic leukemia. The small molecule, dual inhibitor of aminopeptidase and leukotriene A4 hydrolase (LTA4H...
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