BioCentury | Aug 22, 2020
Translation in Brief

IPD’s synthetic bio unlocks target combos for cell therapy; plus Merck’s oral STING agonist, Surrozen’s regenerative therapy and more

...of T cells in conferring long-term immunity against SARS-CoV-2. TARGETSASGR1 (ASGPR; CLEC4H1) – Asialoglycoprotein receptor 1 LGR5 (GPR49...
BioCentury | Jun 17, 2020
Deals

With Ideaya deal, GSK bulks up synthetic lethality side of oncology business

A deal with Ideaya gives GSK a path to growing its synthetic lethality pipeline, a corner of the pharma’s cancer rebuild still primarily centered around PARP inhibitor Zejula. On Tuesday, GlaxoSmithKline plc (LSE:GSK; NYSE:GSK) and...
BioCentury | Jun 13, 2019
Tools & Techniques

GSK teams up with Doudna, Weissman labs to create CRISPR genomics center

GlaxoSmithKline’s latest move to reinvigorate R&D is a collaboration with two of the biggest names in CRISPR research to develop new gene editing technologies and use them to identify drug targets. GlaxoSmithKline plc (LSE:GSK; NYSE:GSK)...
BioCentury | Mar 29, 2019
Targets & Mechanisms

AACR moves in a myeloid direction

...infectious colitis to decrease colorectal cancer risk by modulating the microbiome to upregulate leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5; GPR49...
BioCentury | Oct 11, 2018
Distillery Therapeutics

Cancer

...INDICATION: Basal cell carcinoma (BCC) Mouse studies suggest combining LGR5, LRP6 or PORCN inhibitors with Erivedge...
...BNC101, a humanized mAb targeting LGR5, in preclinical testing for multiple cancers. TARGET/MARKER/PATHWAY: Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5; GPR49...
...email: desauvage.fred@gene.com Claire Quang Erivedge, vismodegib (GDC-0449, RG3616, Systemic Hedgehog Pathway Inhibitor) Free University of Brussels Genentech Inc. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) (GPR49) Low-density...
BioCentury | May 24, 2018
Product R&D

Bias-less bispecifics

...CD3 and CLEC12A, in Phase I/II testing for acute myelogenous leukemia (AML), and MCLA-158 targeting LGR5...
...ERBB3; EGFR3) - Erb-b2 receptor tyrosine kinase 3 NRG1 (HRG1) - Neuregulin LGR5 (GPR49) - Leucine-rich repeat-containing G protein-coupled receptor 5...
BioCentury | May 2, 2018
Distillery Techniques

Chemistry; drug platforms

...In mouse intestinal organoids, the dimeric peptide decreased the number and activity of leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5; GPR49)-positive...
BioCentury | Feb 21, 2018
Distillery Therapeutics

Gastrointestinal

...of damage caused by a tool compound topoisomerase inhibitor, a BBC3 inhibitor decreased levels of LGR5...
...marketed for colorectal and other cancers. TARGET/MARKER/PATHWAY: BCL2 binding component 3 (BBC3; PUMA); leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5; GPR49...
...of Medicine, Pittsburgh, Pa. email: yuj2@upmc.edu Mark Zipkin irinotecan University of Pittsburgh BCL2 binding component 3 (BBC3) (PUMA) Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) (GPR49) Topoisomerase Gastrointestinal...
BioCentury | Jun 2, 2017
Product Development

Ears wide open

...Ear, discovered cochlear progenitor cells that express leucine-rich repeat-containing G protein-coupled receptor ( LGR5 ; GPR49...
...of LGR5-positive support cells. This year, Edge, Langer and Karp described a method of expanding LGR5-positive...
...Inc. Hough Ear Institute Inception 3 Inc. Massachusetts Eye and Ear Novartis AG Otologic Pharmaceutics Inc. Otonomy Inc. Sound Pharmaceuticals Inc. ATOH1 Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) (GPR49) Potassium...
BioCentury | May 11, 2017
Tools & Techniques

Stemming the tide

...Eclipse Therapeutics Inc. 2011 ND ET-101 (BNC-101) Antibody against intestinal stem cell marker leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5; GPR49...
...2015 Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5; GPR49) Colorectal cancer Antibody-drug conjugates targeting the intestinal cancer stem cell marker LGR5...
...adhesion kinase FZD7 - Frizzled homolog 7 FZD8 - Frizzled homolog 8 LGR5 (GPR49) - Leucine-rich repeat-containing G protein-coupled receptor 5...
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