18:21 , Apr 3, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Epilepsy Mouse studies suggest inhibiting COX-2 could help treat autosomal dominant lateral temporal lobe epilepsy (ADLTE), which is caused by LGI1 mutations. In cortex samples from a LGI1-knockout mouse model of ADLTE, levels of COX-2...
08:00 , Jan 22, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Leucine-rich glioma inactivated 1 (LGI1)

Neurology INDICATION: Epilepsy In vitro and mouse studies suggest 4-phenylbutyrate or its analogs could help treat autosomal dominant lateral temporal lobe epilepsy (ADLTE), which is caused by LGI1 mutations with unknown functions. Two transgenic mouse models of...