BioCentury | Jul 3, 2019
Preclinical News

Controlling CAR T toxicity with BMS's Sprycel

...pausing CAR T cell activity. The BCR-ABL tyrosine kinase (BCR-ABL) and Src kinase inhibitor blocks lymphocyte-specific protein tyrosine kinase (LCK)...
...leukemia (ALL) and chronic myelogenous leukemia (CML). Targets: BCR-ABL - BCR-ABL tyrosine kinase; LCK - Lymphocyte-specific protein tyrosine kinase Sandi...
BioCentury | Dec 2, 2016
Emerging Company Profile

Passing CARs

...helps anchor the TACs in lipid rafts where TCRs accumulate. The cytoplasmic domain also binds lymphocyte-specific protein tyrosine kinase (LCK)...
BioCentury | Mar 19, 2015
Distillery Therapeutics

Therapeutics: CXC chemokine receptor 4 (CXCR4; NPY3R); lymphocyte-specific protein kinase (LCK) Provisional patent application filed; available for licensing

...disease INDICATION: Autoimmune disease In vitro studies suggest an antibody-drug conjugate (ADC) targeting CXCR4 and LCK...
...In a human T cell line, an ADC of the anti-CXCR4 antibody conjugated to the LCK...
...chronic myelogenous leukemia (CML). TARGET/MARKER/PATHWAY: CXC chemokine receptor 4 (CXCR4; NPY3R ); lymphocyte-specific protein kinase (LCK)LICENSING...
BioCentury | Oct 24, 2011
Product Development

Kinase by kinase in PAH

...kinases, which include Src; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 ( YES1 ; Yes); lymphocyte-specific protein tyrosine kinase (LCK)...
BioCentury | Apr 23, 2007
Tools & Techniques

High probability pathways

...MAPK14; MAPK11; MAPK13; MAP2K3; MAP3K3; MAPK12; MAP3K4 [45] Integrin signaling BRAF; FYN; MAPK8; MAPK9; RAF1; LCK...
BioCentury | Feb 27, 2006
Product Development

Targeted =/ narrow

...c-kit and platelet-derived growth factor (PDGF) receptor, as well as the Src family tyrosine kinase Lck...
...and PDGFR, which provide its efficacy in GIST. And it binds to the Src kinase Lck...
BioCentury | Sep 9, 2002
Emerging Company Profile

Signase: Src revival

...to Src, Signase is looking to target other members of the Src family such as Lck...
BioCentury | Jul 1, 2002
Company News

Molecular Devices sales and marketing update

...use with its IMAP kinase inhibitor screening technology: PRAK , MSK1 ; Src , Fyn, Lck...
BioCentury | Jan 17, 2000
Emerging Company Profile

Kinetix: Structural themes

...are in immunology, oncology and angiogenesis. The company has identified crystal structures of the kinase Lck...
BioCentury | Dec 20, 1993
Company News

University of Washington other research news

...mice express the cytokine under the direction of the promoter for the lck gene. The lck-IL-4...
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