...pausing CAR T cell activity. The BCR-ABL tyrosine kinase (BCR-ABL) and Src kinase inhibitor blocks lymphocyte-specific protein tyrosine kinase (LCK)...
...leukemia (ALL) and chronic myelogenous leukemia (CML). Targets: BCR-ABL - BCR-ABL tyrosine kinase; LCK - Lymphocyte-specific protein tyrosine kinase Sandi...

...helps anchor the TACs in lipid rafts where TCRs accumulate. The cytoplasmic domain also binds lymphocyte-specific protein tyrosine kinase (LCK)...

...disease INDICATION: Autoimmune disease In vitro studies suggest an antibody-drug conjugate (ADC) targeting CXCR4 and LCK...
...In a human T cell line, an ADC of the anti-CXCR4 antibody conjugated to the LCK...
...chronic myelogenous leukemia (CML). TARGET/MARKER/PATHWAY: CXC chemokine receptor 4 (CXCR4; NPY3R ); lymphocyte-specific protein kinase (LCK)LICENSING...

...kinases, which include Src; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 ( YES1 ; Yes); lymphocyte-specific protein tyrosine kinase (LCK)...

...MAPK14; MAPK11; MAPK13; MAP2K3; MAP3K3; MAPK12; MAP3K4 [45] Integrin signaling BRAF; FYN; MAPK8; MAPK9; RAF1; LCK...

...c-kit and platelet-derived growth factor (PDGF) receptor, as well as the Src family tyrosine kinase Lck...
...and PDGFR, which provide its efficacy in GIST. And it binds to the Src kinase Lck...

...to Src, Signase is looking to target other members of the Src family such as Lck...

...use with its IMAP kinase inhibitor screening technology: PRAK , MSK1 ; Src , Fyn, Lck...

...are in immunology, oncology and angiogenesis. The company has identified crystal structures of the kinase Lck...

...mice express the cytokine under the direction of the promoter for the lck gene. The lck-IL-4...