BioCentury | Aug 14, 2014
Distillery Therapeutics

Indication: Cancer

...and cell culture suggest inhibiting MFGE8 could help treat prostate cancer. In samples from patients, MFGE8...
...healthy controls. In cocultures of apoptotic human prostate cancer cells with bone marrow macrophages, an MFGE8-neutralizing...
...the contribution of MFGE8 to prostate tumor growth in mouse models and designing clinically relevant MFGE8-neutralizing...
BioCentury | Feb 13, 2014
Cover Story

Curb your fatty acids

...the transportersrather than on the proteins themselves and has found that MFGE8 ( lactadherin ; HMFG...
...a connection between MFGE8 and obesity. 3,4 The researchers saw a connection between CD36 and MFGE8...
...or with adding a mutant version of MFGE8 unable to bind to integrin receptors. Conversely, Mfge8...
BioCentury | Feb 13, 2014
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...CD51/CD61) Mouse studies suggest inhibiting MFGE8 could help reduce fat uptake and treat obesity. In Mfge8...
...fed a high-fat diet. In mice treated with recombinant Mfge8, injection of antibodies blocking the Mfge8...
...and enterocyte triglyceride contents compared with control antibody. Next steps include developing antibodies against human MFGE8...
BioCentury | Jan 24, 2013
Distillery Therapeutics

Indication: Inflammation

...allergen-induced asthma, Mfge8 knockout increased asthma-associated airway hyperresponsiveness compared with no knockout. Tracheal rings from Mfge8...
...than rings from wild-type mice. In tracheal rings from humans and Mfge8 knockout mice, recombinant MFGE8...
BioCentury | Jul 21, 2011
Distillery Therapeutics

Indication: Cancer

...Licensing status Publication and contact information Cancer Cancer Lactadherin (MFGE8; HMFG) Mouse studies suggest inhibiting MFGE8...
...chemotherapy resistance. Tumor-associated macrophages in mice with colon or lung cancer stem cells had greater MFGE8...
...in control mice. In mice with cancer stem cell-derived tumors, injection of tumor-associated macrophages from Mfge8/...
BioCentury | Nov 12, 2009
Distillery Therapeutics

Indication: Pulmonary disease

...Mfge8-deficient animals showed greater deposition of collagen and pulmonary fibrosis than nondeficient controls. In the Mfge8-deficient...
...collagen degradation was lower than that in controls. Next steps include showing that administration of MFGE8...
BioCentury | Jun 4, 2009
Distillery Therapeutics

Indication: Cancer

...Cancer Cancer Milk fat globule-EGF factor 8 protein (MFGE8) Studies in mice suggest that blocking MFGE8...
...Studies in mice suggest that blocking MFGE8 could help increase the efficacy of cancer therapeutics. MFGE8...
...levels in diverse tumor types. In mice with colon carcinoma, melanoma or thymoma xenografts, an anti-Mfge8...
BioCentury | Feb 2, 2009
Clinical News

Access Pharmaceuticals preclinical data

...significantly inhibited tumor growth. Additionally, the activity of the humanized IgG1k mAb that binds to Lactadherin...
BioCentury | Jun 30, 2008
Clinical News

Access Pharmaceuticals preclinical data

...and mouse xenograft models, Angiolix blocked new blood vessel formation in tumors. The antibody against lactadherin...
BioCentury | Sep 10, 2007
Clinical News

Access Pharmaceuticals, Somanta preclinical data

...and did not affect normal tissues. Angiolix is a humanized monoclonal antibody that binds to lactadherin...
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