07:00 , Apr 16, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: KISS1 receptor (KISS1R; GPR54); KISS-1 metastasis suppressor (KISS1; kisspeptin)

Endocrine/metabolic disease INDICATION: Hypogonadism In vitro and sheep studies suggest a kisspeptin-based lipopeptide could help treat hypogonadotropic hypogonadism caused by low levels of luteinizing hormone. The lipopeptide consisted of an endogenous kisspeptin peptide modified with a triazole...
07:00 , Oct 17, 2013 |  BC Innovations  |  Targets & Mechanisms

HER2's outside help

An international team has found that neurokinin 1 substance P receptor, a known player in nausea, pain and inflammation, enhances HER2 signaling in breast cancer.1 The findings argue for combining antagonists against both receptors to...
07:00 , Sep 15, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer KISS1 receptor (KISS1R; GPR54) In vitro and mouse studies suggest inhibiting KISS1R could help treat...