BioCentury | Oct 30, 2020
Distillery Therapeutics

KSP as a neuroblastoma target

...By Claire Quang, Staff Writer DISEASE CATEGORY: CancerINDICATION: Neuroendocrine tumorsInhibiting the mitotic kinesin KSP could treat...
...AG (Xetra:VSC) has 4SC-205, an oral inhibitor of KSP, in Phase I testing for solid tumors.TARGET/MARKER/PATHWAY: Kinesin...
...et al. Sci. Transl. Med.; published online Sept. 23, 2020doi:10.1126/scitranslmed.aba4434CONTACT: Daniel Bexell, Lund University, Lund, Swedenemail: daniel.bexell@med.lu.se Claire Quang Lund University Kinesin...
BioCentury | Oct 3, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: September 2018

...3 (METTL3) interaction could help treat lung cancer Boston Children’s Hospital Preclinical News Lung cancer Kinesin...
BioCentury | Sep 10, 2018
Distillery Therapeutics

Cancer

...additional druggable targets involved in metastasis initiation. Apomorphine is marketed to treat Parkinson’s disease. TARGET/MARKER/PATHWAY: Kinesin...
...July 9, 2018 doi:10.1158/0008-5472.CAN-18-1022 CONTACT: Sheila K. Singh, McMaster University, Hamilton, Ontario email: ssingh@mcmaster.ca Alicia Parker McMaster University Kinesin...
BioCentury | Aug 1, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: July 2018

...treat metastatic squamous cell carcinoma (SCC) of the buccal mucosa University of Alberta Distillery Techniques Kinesin...
BioCentury | Jul 18, 2018
Translation in Brief

Playing chicken with metastasis

...screening platform to a metastatic human oral cancer cell line and identified 11 hits, including kinesin...
...and glioblastoma. Jaime de León, Staff Writer EFX001 Entos Pharmaceuticals Inc. University of Alberta CD151 molecule (Raph blood group) (CD151) (TSPAN24) Kinesin...
BioCentury | Jul 18, 2018
Distillery Techniques

Assays and screens

...colony. When applied to human metastatic buccal mucosa squamous cell carcinoma cells, the method identified kinesin...
...Lewis, University of Alberta, Edmonton, Alberta email: jdlewis@ualberta.ca Jaime De Leon Entos Pharmaceuticals Inc. University of Alberta Actin beta (ACTB) Kinesin...
BioCentury | Jun 7, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: May 2018

...UGT8 could help treat basal-like breast cancer. Zhejiang University School of Medicine Distillery Therapeutics Cancer Kinesin...
BioCentury | May 15, 2018
Distillery Therapeutics

Cancer

...in Phase I testing to treat solid tumors. TARGET/MARKER/PATHWAY: Kinesin spindle protein (KSP; Eg5; KIF11); kinesin...
...Steven M. Block, Stanford University, Stanford, Calif. email: sblock@stanford.edu Hongjiang Li filanesib (ARRY-520) Stanford University Kinesin family member 15 (KIF15) Kinesin...
BioCentury | Apr 4, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: March 2018

...of Aspergillus infections in stem cell transplant recipients. University of Aberdeen Distillery Techniques Neurology ALS Kinesin...
BioCentury | Apr 3, 2018
Distillery Techniques

Biomarkers

...animal models of ALS with the KIF5A mutations. DESCRIPTION: Loss-of-function variants and a SNP on kinesin...
...Massachusetts Medical School, Worcester, Mass. email: john.landers@umassmed.edu Jaime De Leon National Institutes of Health University of Massachusetts Medical School Kinesin...
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