22:23 , Mar 23, 2018 |  BC Extra  |  Preclinical News

Paper reveals tissue-specificity of cancer growth genes

A study led by Harvard Medical School and Brigham and Women’s Hospital researchers published in...
18:39 , Mar 2, 2018 |  BC Week In Review  |  Clinical News

Glenmark reports Phase IIa data for anti-OX40 mAb in atopic dermatitis

Glenmark Pharmaceuticals Ltd. (NSE:GLENMARK; BSE:532296) reported data from a placebo-controlled Phase IIa trial in over 60 patients with moderate to severe atopic dermatitis showing that GBR 830 reduced mRNA biomarkers of disease activity, including S100...
21:33 , Dec 16, 2016 |  BioCentury  |  Emerging Company Profile

Floral delivery

Instability and poor penetration can make topical delivery of proteins and peptides into the skin inefficient and inconsistent. Azitra Inc. is using an engineered human commensal strain of bacteria to consistently deliver therapeutic proteins to...
07:00 , Jun 23, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NRF2)

Dermatology INDICATION: Dermatology Patient sample and mouse studies suggest the NFE2L2 activator sulforaphane could help treat pachyonychia congenita, which is caused by mutations in keratin-encoding genes. In patient skin samples, levels of phosphorylated NFE2L2 were...
08:00 , Dec 11, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Pulmonary disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Pulmonary disease Pulmonary disease Tumor protein 63 (TP63; p63); keratin 5 (KRT5) Mouse studies suggest distal airway stem cell transplants could help regenerate lung tissue following...
07:00 , Aug 21, 2014 |  BC Innovations  |  Targets & Mechanisms

Corneal perspectives

Two independent findings could increase the availability of tissue for corneal transplants. A University of California, San Diego -led team has created a new source of limbal stem cells-which are needed for clear vision-by expressing...
07:00 , Jul 24, 2014 |  BC Innovations  |  Cover Story

It is an RNA world

RNA-based molecules have redefined the universe of tractable targets by putting virtually anything that is gene encoded within reach of a disease-modifying agent. This redefinition has launched RNA as the biotech industry's third drug modality....
08:00 , Feb 2, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bladder cancer Keratin 14 (KRT14) Patient sample studies suggest KRT14 could help predict bladder cancer prognosis. In two sets of gene and protein expression data...
08:00 , Feb 2, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bladder cancer Keratin 14 (KRT14) Patient sample studies suggest KRT14 could help predict bladder cancer prognosis. In two sets of gene and protein expression data...
07:00 , Nov 4, 2010 |  BC Innovations  |  Targets & Mechanisms

Stemming ovarian cancer

A Boston team has identified ovarian cancer stem cells that may be responsible for the disease's high relapse rate. 1 The group also discovered that a naturally occurring hormone called anti-Mullerian hormone can wipe out...