BioCentury | Feb 4, 2010
Distillery Therapeutics

Indication: Cancer

...growth factor receptor (EGFR); kelch domain containing 8A (KLHDC8A) Studies in mice and in cell culture suggest that inhibiting KLHDC8A...
...resistance to EGFR-targeted therapies. In mice with EGFR-resistant glioma cells, small hairpin RNA-mediated knockdown of Klhdc8a...
...reduced tumor formation compared with that seen using control shRNA. Next steps include studying how KLHDC8A...
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