BioCentury | Nov 2, 2018
Targets & Mechanisms

FDA’s pediatric target picks

FDA is looking ahead of industry in its guideline on targets for pediatric oncology, which includes more than 50 not yet in company pipelines in a list of over 220 the agency has its eye...
BioCentury | Sep 13, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: August 2018

New Therapeutic Targets and Biomarkers: August 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in August 2018. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Aug 8, 2018
Distillery Therapeutics

Cancer

INDICATION: Liver cancer; B cell lymphoma Zebrafish and mouse studies identified inhibitors of KAT6A and KAT6B that could help treat hepatocellular carcinoma (HCC) and B cell lymphoma. In vitro screening of a small molecule library...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...
BioCentury | Oct 10, 2017
Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling A panel of 17 genomic loci could help predict the risk of PD. Genome-wide association studies in a total of 20,084 PD patients and 397,324 healthy volunteers identified associations between the disease...
BioCentury | Oct 4, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: September 2017

New Therapeutic Targets and Biomarkers: September 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during September 2017. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Sep 27, 2017
Distillery Techniques

Chemistry

TECHNOLOGY: Synthetic chemistry A scalable, cobalt nanoparticle-based method for incorporating amine functional groups into drug-like molecules could facilitate drug production and the exploration of chemical space. The nanoparticles consist of a cobalt core encapsulated in...
BioCentury | Sep 21, 2017
Tools & Techniques

On your marks

...and CML Histone acetyltransferase K(lysine) acetyltransferase 2B (KAT2B; PCAF) Cancer; endocrine / metabolic Brain cancer; diabetes Inhibiting KAT2B...
...PCAF) Cancer; endocrine / metabolic Brain cancer; diabetes Inhibiting KAT2B could help treat brain cancer; KAT2B...
BioCentury | Sep 12, 2017
Preclinical News

Researchers identify 17 new PD risk loci

In a paper published in Nature Genetics , researchers from the Genentech Inc. unit of Roche (SIX:ROG; OTCQX:RHHBY), 23andMe Inc. (Mountain View, Calif.) and colleagues conducted a meta-analysis of genome-wide association studies (GWAS) and identified 17...
BioCentury | Jan 31, 2017
Distillery Techniques

Chemistry

...TECHNOLOGY: Tool compounds An aminopyridazinone-based compound that inhibits the KAT2A and KAT2B bromodomains could be useful...
...and KAT2B with the same K i value (1.4 nM) and inhibited the bromodomain of KAT2B...
...cancer. DESCRIPTION: Tool compound for probing the roles of K(lysine) acetyltransferase 2A (KAT2A) and KAT2B (PCAF...
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