New Therapeutic Targets and Biomarkers: December 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during December. Therapeutic targets are defined as any protein, gene or other molecule...

INDICATION: Anxiety Mouse studies suggest inhibiting KPNA1 or its downstream mediator the S1P receptor could help treat anxiety. In a mouse model of anxiety, systemic KPNA1 knockout or intrahippocampal injection of an shRNA targeting KPNA1...

New Therapeutic Targets and Biomarkers: March 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during March 2018. Therapeutic targets are defined as any protein, gene or other...

INDICATION: Ataxia Cell culture, fruit fly and mouse studies suggest inhibiting KPNA3 could help treat spinocerebellar ataxia type 3 (SCA3), which is caused by mutant ATXN3 containing polyglutamine repeats that accumulates in the nucleus. In...

Understanding the basic biology of amyotrophic lateral sclerosis (ALS) is still the biggest barrier to a serious breakthrough in the disease, despite the fact that genetic studies have pointed to some clear culprits for a...