19:58 , Sep 21, 2017 |  BC Innovations  |  Tools & Techniques

On your marks

With less fanfare than the first two waves, a quiet rise in activity is driving a revival of interest in epigenetics, despite little progress in solving the fundamental challenges that have dogged the field from...
22:54 , Jan 31, 2017 |  BC Innovations  |  Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds An aminopyridazinone-based compound that inhibits the KAT2A and KAT2B bromodomains could be useful for probing the role of the two enzymes in cancer. Screening of a library of acetyl-lysine-containing small molecules in...
07:00 , Oct 17, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine/metabolic disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Diabetes K(lysine) acetyltransferase 2B (KAT2B; PCAF) Mouse studies suggest antagonizing KAT2B could help lower glucose levels and help treat type...
07:00 , Sep 26, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer K(lysine) acetyltransferase 2B (KAT2B; PCAF) Cell culture and mouse studies suggest inhibiting PCAF could help treat brain cancer by...