19:32 , Sep 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Encephalopathy Patient sample and mouse studies suggest inhibiting the JAK/STAT1 pathway, the interaction between MCP-1 and CCR2, or phagocyte activation could help treat Rasmussen encephalitis. In postmortem brain samples from patients, levels of phosphorylated STAT1...
18:29 , Aug 31, 2018 |  BC Week In Review  |  Company News

Sierra Oncology acquires momelotinib from Gilead

Sierra Oncology Inc. (NASDAQ:SRRA) acquired momelotinib (formerly CYT387) from Gilead Sciences Inc. (NASDAQ:GILD) for $3 million up front and up to $195 million in milestones. Gilead is also eligible for tiered royalties ranging from mid-teens...
17:52 , Aug 29, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Cancer; cervical cancer; head and neck cancer; lung cancer; ovarian cancer Patient sample, cell culture and mouse studies suggest inhibiting MAST1 could help treat cisplatin-resistant cancer. In tumor samples from squamous cell carcinoma of...
16:05 , Aug 16, 2018 |  BC Innovations  |  Distillery Therapeutics

Gastrointestinal

INDICATION: Gastrointestinal Mouse studies suggest inhibiting JAK-1 and JAK-2, RAG2 or IL-6 could help treat Peutz-Jeghers syndrome, which involves the formation of benign gastrointestinal polyps. In a mouse model of the disease, systemic knockout of RAG2...
19:22 , Jul 13, 2018 |  BC Week In Review  |  Clinical News

Incyte's Jakafi meets in Phase II for steroid-refractory GvHD

Incyte Corp. (NASDAQ:INCY) said Jakafi ruxolitinib in combination with corticosteroids met the primary endpoint in the U.S. Phase II REACH1 trial to treat steroid-refractory acute graft-versus-host disease (GvHD). The company plans to submit an sNDA...
21:38 , Jul 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer; infectious disease

INDICATION: Acute myelogenous leukemia (AML); Candida In vitro, cell culture and mouse studies identified an aminopyrimidine-based dual JAK-2/HDAC6 inhibitor that could help treat AML and Candida albicans infection. Chemical synthesis of aminopyrimidine analogs linked to hydroxamic...
03:04 , Jun 30, 2018 |  BioCentury  |  Finance

Eyes on launches

The annual summer slowdown isn’t restricted to just the stock market this year, as the clinical catalyst calendar also appears to be on holiday in 3Q18. Buysiders are therefore turning their attention to a spate of...
20:22 , Jun 15, 2018 |  BC Week In Review  |  Clinical News

Lilly planning Phase III trials for Olumiant in lupus

Eli Lilly and Co. (NYSE:LLY) said it plans to start this year Phase III testing of Olumiant baricitinib to treat systemic lupus erythematosus (SLE) after reporting that the higher dose of the drug met the...
21:26 , Jun 13, 2018 |  BC Extra  |  Clinical News

Lilly planning Phase III trials for Olumiant in lupus

Eli Lilly and Co. (NYSE:LLY) said it plans to start this year Phase III testing of Olumiant baricitinib to treat systemic lupus erythematosus (SLE) after reporting that the higher dose of the drug met the...
18:29 , Jun 8, 2018 |  BC Week In Review  |  Clinical News

FDA approves Lilly's Olumiant for RA

FDA approved Olumiant baricitinib from Eli Lilly and Co. (NYSE:LLY) and partner Incyte Corp. (NASDAQ:INCY) to treat moderate to severe rheumatoid arthritis in patients who have responded poorly to one or more TNF antagonists. Lilly intends...