16:58 , May 31, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Cell culture and mouse studies identified a JAG2-targeting MT-TL1 fragment that could help treat colorectal cancer. The fragment consisted of a dicer 1 ribonuclease type III (DICER1)-cleaved form of MT-TL1 and targeted the...
08:00 , Jan 21, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Jagged 1 (JAG1); JAG2

Inflammation INDICATION: Asthma Mouse studies suggest inhibiting JAG1 and JAG2 could help treat asthma. In mice, a combination of anti-JAG1 and anti-JAG2 mAbs increased the numbers of mucus-clearing ciliated cells in the lungs compared with an inactive...
08:00 , Jan 8, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Notch 1 (NOTCH1); jagged 1 (JAG1); jagged 2 (JAG2)

Cancer INDICATION: Cancer In vitro and mouse studies suggest inhibiting JAG-mediated NOTCH1 signaling could help treat cancer by inhibiting angiogenesis. In an in vitro angiogenesis assay, human endothelial cells expressing NOTCH1 decoy proteins that inhibited binding of...