BioCentury | Mar 22, 2018
Distillery Therapeutics

Endocrine / Metabolic

...identified associations between loss-of-function mutations in ZMPSTE24 and the disease. In a yeast model of IAPP-induced...
...the yeast homolog of ZMPSTE24 or expression of ZMPSTE24 decreased endoplasmic reticulum (ER) stress and IAPP-induced...
...testing promoters of ZMPSTE24 expression in animal models of diabetes. TARGET/MARKER/PATHWAY: Zinc metallopeptidase STE24 (ZMPSTE24); islet amyloid polypeptide (IAPP)...
BioCentury | Mar 10, 2018
Preclinical News

Increasing ZMPSTE24 could help treat, prevent Type II diabetes

...or prevent Type II diabetes. IAPP is co-secreted with insulin to promote glycemic regulation. However, IAPP...
...of Technology first created a Saccharomyces cerevisiae yeast model of IAPP toxicity, in which an IAPP...
...and IAPP-induced growth defects compared with normal STE24 expression. In a pancreatic cell line overexpressing IAPP...
BioCentury | Dec 1, 2016
Targets & Mechanisms

Not a peripheral story

...17 that reacted with known antigens, including long-established ones as well as a hybrid insulin- IAPP...
...University of Massachusetts Medical School, Worcester, Mass. Targets GAD - Glutamic acid decarboxylase IAPP - Islet amyloid polypeptide...
BioCentury | Aug 28, 2014
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Diabetes Islet amyloid polypeptide (IAPP) In vitro and...
...In vitro and mouse studies suggest enhancing b cell autophagy could help treat diabetes. Human IAPP...
...cell viability and inhibiting autophagy decreased viability compared with normal autophagy. In mice expressing human IAPP...
BioCentury | Sep 30, 2013
Company News

KalVista ophthalmic news

...is funded by a €1.7 million ($2.2 million) Marie Curie Industry-Academia Pathways and Partnerships ( IAPP...
BioCentury | Sep 20, 2010
Product Development

Clearing The Cobwebs

...partner. The company has two discovery programs in Type II diabetes aimed at clearing misfolded islet amyloid polypeptide (IAPP)...
BioCentury | Aug 28, 2008
Distillery Therapeutics

This Week in Therapeutics

...contact information Endocrine disease Diabetes; Alzheimer's disease (AD) Islet amyloid polypeptide (IAPP) In vitro studies suggest that an IAPP...
...and fibrillogenesis of insulin. In cell culture, insulin plus IAPP-GI did not affect insulin signaling. IAPP-GI...
...it might also help treat AD. Further studies are necessary to assess the effects of IAPP-GI...
BioCentury | Jul 18, 2005
Emerging Company Profile

Innodia: Surrounding diabetes

...orally available molecule next year. Innodia's earliest stage program is a series of islet-associated polypeptide (IAPP...
BioCentury | May 21, 2001
Company News

Crucell, University Medical Center Utrecht deal

...the university's transgenic mouse model, which measures the prevention and elimination of aggregation of human islet amyloid polypeptide...
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