15:48 , Feb 28, 2019 |  BC Innovations  |  Distillery Therapeutics

Inflammation

INDICATION: Inflammation Cell culture and mouse studies suggest IL-37 could help treat inflammation. In mouse macrophages treated with lipopolysaccharide (LPS), transgenic expression of human IL-37 decreased inflammatory cytokine levels compared with no transgene expression. In...
07:00 , Sep 1, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Gastrointestinal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Gastrointestinal disease Colitis IL-37 (IL-1F7) Mouse studies suggest upregulating IL-37 could help treat colitis. In a mouse model of chemical-induced colitis, expression of human IL-37 led...
07:00 , May 5, 2011 |  BC Innovations  |  Targets & Mechanisms

Breast cancer therapy with IL-25

A team of U.S. and Taiwan researchers has shown that IL-25, a proinflammatory cytokine involved in allergic inflammation, also exerts potent cytotoxic effects in breast cancer cells and decreases mammary tumor growth in mice. 1...