BioCentury | Aug 11, 2017
Strategy

The flip-side of immunotherapy

...InterWest and a pair of corporate VCs, Tizona is inhibiting Treg targets including CCR4 and IL-35...
...Interferon γ IL-1 - Interleukin-1 IL-2 - Interleukin-2 IL-17 - Interleukin-17 IL-18 - Interleukin-18 IL-35...
BioCentury | Feb 28, 2017
Distillery Therapeutics

Cancer

...INDICATION: Pancreatic cancer Patient, cell culture and mouse studies suggest inhibiting IL-35 could help treat metastatic...
...metastatic human PDAC cell lines co-cultured with human umbilical vein endothelial cells (HUVECs), knockdown of IL-35...
...onto the pancreas, tumor-specific knockdown of IL-35 decreased liver metastasis. Next steps could include identifying IL-35...
BioCentury | Mar 14, 2016
Finance

Abingworth's early action

...Pablo Cagnoni. The two disclosed targets are CC chemokine receptor 4 (CCR4; CD194 ) and IL-35...
...Blocking CCR4 depletes the number of immunosuppressive regulatory T cells in the tumor microenvironment. IL-35...
BioCentury | Mar 27, 2014
Distillery Therapeutics

Indication: Various

...status Publication and contact information Various Autoimmune disease; infectious disease IL-35 Mouse studies suggest enhancing IL-35-producing...
...genes required for IL-35 production exacerbated disease and autoreactive T cell activity. In mice with IL-35-deficient...
...T cell activity. Next steps could include identifying therapeutics that modulate B cell production of IL-35...
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