BioCentury | May 16, 2019
Company News

Genentech adds to autoimmune pipeline with Parvus deal

...testing for ulcerative colitis and Crohn’s disease; IL22-Fc (UTTR1147A, RG7880), a recombinant human protein against IL-22...
...other indications, including multiple sclerosis and RA. Targets: Btk - Bruton's tyrosine kinase; IL-22 - Interleukin-22 Chris...
BioCentury | Feb 21, 2019
Translation in Brief

Bugging inflammation in lung cancer

...Targets: IL-1β - Interleukin-1β; IL-12 - Interleukin-12 ; IL-17A - Interleukin-17A; IL22RA1 (IL22R; IL22R1) - Interleukin-22...
BioCentury | Feb 20, 2019
Distillery Therapeutics

Cancer

...mAb targeting IL22RA1, in preclinical testing for atopic dermatitis and skin inflammation. TARGET/MARKER/PATHWAY: Interleukin-17A (IL-17A); interleukin-22...
BioCentury | Nov 13, 2018
Distillery Therapeutics

Hepatic

...help treat liver fibrosis. In liver tissue samples from hepatitis patients, levels of IL-17A and IL-22...
BioCentury | Sep 7, 2018
Clinical News

Abivax's ABX464 improves mucosal healing, Mayo Score in Phase IIa for UC

...with the cap binding complex (CBC) Indication: Treat moderate to severe ulcerative colitis Endpoint: Safety; IL-22...
BioCentury | May 30, 2018
Distillery Therapeutics

Cancer

...INDICATION: Lung cancer Patient sample and mouse studies suggest inhibiting IL-22 could help treat KRAS-mutant lung...
...help treat KRAS-mutant lung cancer. In KRAS-mutant lung adenocarcinoma patients, high tumor levels of the IL-22...
...could include identifying and testing IL-22 inhibitors in additional models of lung cancer. TARGET/MARKER/PATHWAY: Interleukin-22 (IL-22); IL-22...
BioCentury | May 17, 2018
Preclinical News

Inhibiting IL-22 could treat KRAS-mutant lung cancer

...Center suggests inhibiting IL-22 could help treat KRAS-mutant lung cancer. High levels of IL-22 and IL-22-positive...
...IL-22 receptor subunit alpha 1 (IL22RA1; IL22R; IL22R1), which was associated with poor overall survival. IL-22...
...and size as well as tumor cell proliferation and angiogenesis compared with normal IL-22 expression. IL-22...
BioCentury | May 18, 2017
Product R&D

Making cells compute

...detected pathogenically high levels of insulin, glucose, thyroid hormones, or the combination of TNFα and IL-22...
...GLP-1 - Glucagon-like peptide-1 IL-4 - Interleukin-4 IL-10 - Interleukin-10 IL-12 - Interleukin-12 IL-22 - Interleukin-22...
BioCentury | Nov 3, 2016
Translation in Brief

The I’s have it

...TNFα) work in part by downregulating interleukin-22 receptor subunit alpha 2 (IL22RA2; IL-22BP) to increase IL-22...
...IL-22 has also been found to cause intestinal diseases, including cancer, calling into question whether IL-22...
...thinks targeting IL22RA2 could have advantages over inhibiting TNFα or delivering recombinant IL-22. He said IL-22...
BioCentury | Oct 27, 2016
Targets & Mechanisms

Cancer’s Phoenix

...the efficacy.” In addition, he noted there are other emerging cytokines such as IL-15 and IL-22...
...Compounds CD25 - Interleukin-2 receptor α chain IL-2 - Interleukin-2 IL-15 - Interleukin-15 IL-22 - Interleukin-22...
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