20:06 , Aug 1, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Ovarian cancer Cell culture and mouse studies suggest adoptive transfer of CD56-expressing autologous or allogeneic NK cells could help treat ovarian cancer. Primary human NK cells cultured with IL-2 to induce activation and an IL-21-expressing...
16:29 , Feb 7, 2018 |  BC Innovations  |  Distillery Techniques

Drug platforms

TECHNOLOGY: Cell therapy CAR T cells engineered to contain a JAK-STAT signaling domain could enhance proliferation and persistence of T cell therapies for cancer. The engineered CAR T cells consisted of standard CD19-targeting CARs engineered with...
00:34 , Feb 6, 2018 |  BC Extra  |  Preclinical News

JAK-STAT signaling could improve CAR T efficacy, persistence

In a paper published in Nature Medicine, researchers at University Health Network and University of Toronto suggested that adding a cytokine engagement domain to chimeric antigen receptor (CAR) T cells could increase both proliferation and...
01:20 , Jan 4, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Hepatitis B virus (HBV) Mouse studies suggest promoting the expression of IL-21 or IL-33 could help treat HBV infection. In two mouse models of HBV, IV injection of plasmids encoding IL-21 or IL-33 decreased levels...
00:53 , Jun 8, 2017 |  BC Innovations  |  Emerging Company Profile

Killer expansion

CytoSen Therapeutics Inc.'s nanoparticle technology expands and activates patient-derived NK cells ex vivo with fewer safety risks and manufacturing challenges than other expansion protocols. Unlike T cells, which mount highly specific immune responses to pathogens or...
12:08 , May 24, 2017 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on six genomic loci could help predict the risk of primary biliary cholangitis. Genome-wide association studies in 2,029 PBC patients and 6,163 healthy volunteers from the Han Chinese population identified independent associations between...
00:41 , Mar 25, 2017 |  BioCentury  |  Strategy

Mountain climbing

U.S. pricing pressure on insulin and hemophilia products have caused Novo Nordisk A/S to guide for negative sales and operating profit growth for the first time ever. While newly launched diabetes and obesity products are...
19:07 , Jan 18, 2017 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Lupus Cell culture and mouse studies suggest inhibiting TNFRSF21 could help treat lupus. In spleens from a mouse model of lupus, the number of TNFRSF21-positive follicular helper T (Tfh) cells was higher than in normal...
07:00 , Aug 1, 2016 |  BC Extra  |  Financial News

Bioniz raises $13M in series A round

Bioniz Therapeutics Inc. (Irvine, Calif.) raised $13 million in a series A round co-led by the Takeda Ventures unit of Takeda Pharmaceutical Co. Ltd. (Tokyo:4502) and David Pyott, the former chairman and CEO of Allergan...
08:00 , Feb 11, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Interleukin-21 (IL-21)

Infectious disease INDICATION: HIV / AIDS Monkey studies suggest combining IL-21 with antiretroviral therapy (ART) could help treat HIV/AIDS. In simian immunodeficiency virus (SIV)-infected macaques, six weekly injections of IL-21 plus daily ART increased the numbers of...