BioCentury | Aug 29, 2020
Product Development

Next-wave Th1 cytokine cancer therapies aim for more precise targeting

...ɣ chain IL-12 – Interleukin-12IL-18 – Interleukin-18 IL-18BP – Interleukin-18 (IL-18) binding protein Karen...
BioCentury | Jun 25, 2020
Emerging Company Profile

Simcha launches with $25M WuXi-led series A, new take on IL-18 for cancer

...his team keyed in on IL18BP as a cause for the ineffectiveness of recombinant IL-18. IL18BP...
...mouse IL-18 that could still signal through the IL-18 receptor but would no longer bind IL18BP...
...China and Connecticut Innovations, Pfizer Ventures Chairman: Aaron Ring Patents: Undisclosed Targets IL-18 - Interleukin-18 IL18BP...
BioCentury | Mar 27, 2018
Distillery Therapeutics


INDICATION: Multiple myeloma (MM) Patient sample and mouse studies suggest inhibiting IL-18 or NLRP1 could help treat MM. In patient samples, high bone marrow plasma levels of IL-18 correlated with poor overall survival. In two...
BioCentury | Jan 17, 2018
Distillery Therapeutics


INDICATION: Gastric cancer Patient sample and mouse studies suggest inhibiting PYCARD or its downstream effector IL-18 could help treat gastric cancer. In tumor samples from patients, levels of PYCARD and IL-18 were higher than in...
BioCentury | Jun 9, 2016
Translation in Brief

Stopping sepsis

...infants hospitalized with sepsis, in whom high plasma levels of IL-18 and IL-18 binding protein (IL18BP...
BioCentury | Nov 16, 2015
Clinical News

IL-18BP: Compassionate use program data

AB2 said a 3-month old girl with macrophage activation syndrome due to a genetic mutation of the NRL family CARD domain containing 4 (NLRC4) gene was in full remission after receiving 3 months of treatment...
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