BioCentury | Mar 12, 2020
Product Development

With initial PKU trial ‘uninterpretable,’ Rubius turns to cancer, autoimmune diseases

...a red blood cell therapeutic that co-expresses 4-1BBL and IL-15TP, a fusion of IL-15 and IL-15RA...
...fell to about $320 million. Targets 4-1BBL (TNFSF9; CD137L) - 4-1BB ligand IL-15 - Interleukin-15 IL-15RA...
BioCentury | Feb 7, 2019
Company News

Xencor to co-develop IL-15 therapies with Genentech

...use." According to Horn, XmAb24306 will be Genentech's first IL-15 drug candidate. XmAb24306, an engineered IL-15/IL-15RA...
...modifications made to IL-15 to optimize the cytokine's potency. He also said linking IL-15 with IL-15RA...
...of Roche (SIX:ROG; OTCQX:RHHBY). Xencor gained $0.10 to $36.54 Feb. 5. IL-15 - Interleukin 15; IL-15RA...
BioCentury | Feb 5, 2019
Company News

Xencor to co-develop IL-15 therapies with Genentech

...use." According to Horn, XmAb24306 will be Genentech's first IL-15 drug candidate. XmAb24306, an engineered IL-15/IL-15RA...
...modifications made to IL-15 to optimize the cytokine's potency. He also said linking IL-15 with IL-15RA...
...Tuesday. IL-15 - Interleukin 15; IL-15RA - Interleukin 15 receptor α chain Sandi Wong Genentech Inc. Roche Xencor Inc. Interleukin-15 (IL-15) Interleukin-15 (IL-15) receptor alpha chain (IL-15RA) Cancer...
BioCentury | Jan 25, 2019
Product R&D

Rubius turns immunotherapy red

...costimulatory and cytokine signals. RTX-240’s membrane is embedded with a fusion protein of IL-15 and IL-15RA...
...CD137L) - 4-1BB ligand HLA - Human leukocyte antigen IL-12 - Interleukin-12 IL-15 - Interleukin-15 IL-15RA...
BioCentury | Jun 9, 2018
Product Development

POC for cytokines

...signals through the intermediate-affinity IL-2 receptor only in the presence of IL-15RA. Fusing IL-15 to IL-15RA...
BioCentury | Dec 14, 2017
Emerging Company Profile

Backpacks for CARs

...premise of our technology,” Henderson told BioCentury. Novartis AG and Altor BioScience Corp. each have IL-15/IL-15RA...
...a paper published in 2010 that first described the technology, Irvine also combined IL-15 with IL-15RA...
...SIX:NOVN), Basel, Switzerland Torque Therapeutics Inc., Cambridge, Mass. Targets IL-12 - Interleukin-12 IL-15 - Interleukin-15 IL-15RA...
BioCentury | Dec 9, 2017
Product Development

Multimodal meeting

...ALT-803 IL-15 mutant agonist complexed to an Fc fusion protein of IL-15 receptor alpha chain (IL-15RA...
BioCentury | Jul 7, 2017
Company News

NantWorks acquires Altor BioScience

...an IL-15 mutant agonist complexed to an Fc fusion protein of IL-15 receptor a-chain (IL-15RA...
...Corp. , Miramar, Fla. NantWorks LLC , Los Angeles, Calif. Business: Cancer Shannon Lehnbeuter ALT-803 Altor BioScience Corp. NantWorks LLC Interleukin-15 (IL-15) receptor alpha chain (IL-15RA)...
BioCentury | Apr 7, 2017
Finance

Combo quest

...an IL-15 mutant agonist complexed to an Fc fusion protein of IL-15 receptor alpha chain (IL-15RA...
BioCentury | Jan 27, 2017
Clinical News

Allogeneic aNK cells: Preliminary Ph II QUILT-3.009 data

...an IL-15 mutant agonist complexed to an Fc fusion protein of IL-15 receptor a-chain (IL-15RA...
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