BioCentury | Jun 18, 2020
Emerging Company Profile

Lassen emerges from Frazier with over $31M and a mAb for fibrosis and cancer

...also demonstrated that reducing IL-11 levels in mice could reduce cardiac and renal fibrosis (see “IL-11...
...and DC Investment Partners CEO: Mark Barrett Patents: Undisclosed Targets IL-11 - Interleukin-11 IL-11R - Interleukin-11 receptor...
...IL-11R - Interleukin-11 receptor PD-1 (PDCD1; CD279) - Programmed cell death 1 Sandi Wong, Assistant Editor Frazier Healthcare Partners Interleukin-11 (IL-11) receptor Lassen...
BioCentury | Jan 10, 2020
Company News

Boehringer continues fibrosis drive via acquisition of Enleofen assets

...The acquisition of Enleofen’s preclinical IL-11 inhibition platform is the latest in a string of deals...
...targeting IL-11 in areas including inflammation and tissue regeneration. According to Cook, an antibody blocking IL-11...
...and co-founder and CEO of Engine Biosciences Pte. Ltd. Targets: IL-11 - Interleukin-11; IL11RA - Interleukin-11 receptor...
BioCentury | Oct 28, 2019

Enleofen co-founders identify IL-11 as pulmonary fibrosis target

...Stuart Cook and Sebastian Schafer showed that inhibiting IL-11 could treat pulmonary fibrosis. Levels of IL-11...
...122 IPF patients than in samples from 92 healthy volunteers, and among the patients, high IL-11...
...with the anti-IL-11 mAbs ENx108A and ENx209 in preclinical studies for multiple fibrotic diseases. TARGET/MARKER/PATHWAY: Interleukin-11 (IL-11)...
BioCentury | Dec 5, 2017
Distillery Therapeutics

Cardiovascular; renal

...INDICATION: Cardiovascular; renal Cell culture and mouse studies suggest inhibiting IL-11 could treat cardiac and renal...
...IL-11 in fibrosis of other tissues, such as the liver, lungs, skin and eyes. TARGET/MARKER/PATHWAY: IL-11...
...2017 doi:10.1038/nature24676 CONTACT: Stuart Cook, National Heart Centre Singapore, Singapore email: stuart.cook@duke-nus.edu.sg Jennie Walters Enleofen Bio Pte. Ltd. IL-11 Cardiovascular...
BioCentury | Nov 15, 2017
Preclinical News

Researchers identify IL-11 as new target for cardiovascular fibrosis

...that IL-11 upregulation was the dominant transcriptional response to TGFB1 exposure. In cardiac fibroblasts, increased IL-11...
...MI), recombinant mouse IL-11 led to epicardium fibroblast activation and ventricular impairment compared with vehicle. IL-11...
...renal impairment, suggesting upregulation of IL-11 is crucial for TGFB1 pro-fibrotic effects. Transgenic mice overexpressing IL-11...
BioCentury | Jul 13, 2017
Preclinical News

IL-11 receptor inhibition tied to osteosarcoma

...the National Academy of Sciences , researchers showed that targeting the alpha subunit of the IL-11...
...overall survival. In human metastatic osteosarcoma cells, the scientists found IL-11R alpha and its ligand IL-11...
...New Mexico, University of Michigan and Harvard Medical School. Chris Lieu Neumega VM501 Arrowhead Pharmaceuticals Inc. Pfizer Inc. Shire plc ViroMed Co. Ltd. Interleukin-11 (IL-11) receptor...
BioCentury | Sep 12, 2013
Distillery Therapeutics

Indication: Cancer

...information Cancer Gastrointestinal cancer IL-11; IL-11 receptor Studies in human samples and mice suggest inhibiting IL-11...
...cancers. In patient tumor samples and in a mouse model of chemically induced colorectal cancer, IL-11...
...IL-11. SciBX 6(35); doi:10.1038/scibx.2013.958 Published online Sept. 12, 2013 The concept of using anti-IL-11 or anti-IL-11...
BioCentury | Apr 15, 2013
Clinical News

Neumega interleukin-11 data

...Institute published in the Journal of Clinical Oncology the results of a placebo-controlled trial of IL-11...
...by placebo or 50 µg/kg/day of IL-11 subcutaneously for 10-17 days. Of 40 patients given IL-11...
...require platelet transfusions, compared to 15 of 37 (41 percent) in the placebo group (p=0.04). IL-11...
BioCentury | Mar 21, 2013
Distillery Therapeutics

Indication: Cancer

...status Publication and contact information Cancer Cancer IL-11 Mouse and cell culture studies suggest inhibiting IL-11...
...help treat hypoxic solid tumors. Human colorectal cancer cells cultured under hypoxic conditions had greater IL-11...
...oxygen conditions. In a mouse xenograft model for human prostate cancer, small hairpin RNA against IL-11...
BioCentury | Dec 24, 2012
Product Development

Shire homes in

...with its BMTP-11 in a Phase I study in metastatic prostate cancer. BMTP-11 targets the IL-11...
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