19:34 , Dec 5, 2017 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular; renal

INDICATION: Cardiovascular; renal Cell culture and mouse studies suggest inhibiting IL-11 could treat cardiac and renal fibrosis. In mouse models of cardiac fibrosis and kidney damage, IL-11 knockout decreased heart fibrosis and renal fibrosis compared with...
21:51 , Nov 15, 2017 |  BC Extra  |  Preclinical News

Researchers identify IL-11 as new target for cardiovascular fibrosis

A study published in Nature by researchers at Duke-NUS Graduate Medical School and colleagues showed that inhibiting IL-11 prevented fibroblast activation in cardiac tissues, suggesting a new target to treat cardiovascular fibrosis. While transforming growth factor...
01:41 , Jul 13, 2017 |  BC Extra  |  Preclinical News

IL-11 receptor inhibition tied to osteosarcoma

In a paper published in Proceedings of the National Academy of Sciences, researchers showed that targeting the alpha subunit of the IL-11 receptor (IL-11R) with the bone metastasis-targeting peptidomimetic BMTP-11 reduces metastases and tumor growth....
07:00 , Sep 12, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Gastrointestinal cancer IL-11; IL-11 receptor Studies in human samples and mice suggest...
07:00 , Apr 15, 2013 |  BC Week In Review  |  Clinical News

Neumega interleukin-11 data

Genetics Institute published in the Journal of Clinical Oncology the results of a placebo-controlled trial of IL-11 in women with high-risk breast cancer and low platelet counts due to chemotherapy. A total of 77 women...
07:00 , Mar 21, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer IL-11 Mouse and cell culture studies suggest inhibiting IL-11 signaling could...
08:00 , Dec 24, 2012 |  BioCentury  |  Product Development

Shire homes in

Proof-of-concept data in cancer for Arrowhead Research Corp.'s peptide-based tissue targeting platform were good enough to get Shire plc on board to use the technology for rare diseases. Last week, the companies partnered to use Arrowhead's...
08:00 , Feb 2, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Hepatic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Hepatic disease Liver disease IL-11 receptor In vitro and mouse studies suggest agonizing the IL-11 receptor could help...
08:00 , Feb 2, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bladder cancer Keratin 14 (KRT14) Patient sample studies suggest KRT14 could help predict bladder cancer prognosis. In...
08:00 , Dec 8, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bone cancer IL-11 receptor-a (IL11RA) In vitro, mouse and patient sample studies suggest T cells modified to...