19:34 , Dec 5, 2017 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular; renal

INDICATION: Cardiovascular; renal Cell culture and mouse studies suggest inhibiting IL-11 could treat cardiac and renal fibrosis. In mouse models of cardiac fibrosis and kidney damage, IL-11 knockout decreased heart fibrosis and renal fibrosis compared...
21:51 , Nov 15, 2017 |  BC Extra  |  Preclinical News

Researchers identify IL-11 as new target for cardiovascular fibrosis

A study published in...
01:41 , Jul 13, 2017 |  BC Extra  |  Preclinical News

IL-11 receptor inhibition tied to osteosarcoma

In a paper published in...
07:00 , Sep 12, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Gastrointestinal cancer IL-11; IL-11 receptor Studies in human samples and mice suggest inhibiting IL-11 signaling could help treat gastrointestinal cancers. In...
07:00 , Apr 15, 2013 |  BC Week In Review  |  Clinical News

Neumega interleukin-11 data

Genetics Institute published in the Journal of Clinical Oncology the results of a placebo-controlled trial of IL-11 in women with high-risk breast cancer and low platelet counts due to chemotherapy. A total of 77 women...
07:00 , Mar 21, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer IL-11 Mouse and cell culture studies suggest inhibiting IL-11 signaling could help treat hypoxic solid tumors. Human colorectal cancer cells...
08:00 , Dec 24, 2012 |  BioCentury  |  Product Development

Shire homes in

Proof-of-concept data in cancer for Arrowhead Research Corp. 's peptide-based tissue targeting platform were good enough to get Shire plc on board to use the technology for rare diseases. Last week, the companies partnered to...
08:00 , Feb 2, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Hepatic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Hepatic disease Liver disease IL-11 receptor In vitro and mouse studies suggest agonizing the IL-11 receptor could help treat liver damage. In a mouse model of...
08:00 , Feb 2, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bladder cancer Keratin 14 (KRT14) Patient sample studies suggest KRT14 could help predict bladder cancer prognosis. In two sets of gene and protein expression data...
08:00 , Dec 8, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bone cancer IL-11 receptor-a (IL11RA) In vitro, mouse and patient sample studies suggest T cells modified to express IL11RA could help treat osteosarcoma. In 14...