02:11 , Dec 8, 2017 |  BC Innovations  |  Targets & Mechanisms

Pathways emerging from ASH

A survey of the emerging molecular targets at this year’s American Society of Hematology conference indicates that while harnessing the immune system to treat cancer remains a dominant interest, processes for tuning protein levels --...
07:00 , Jul 28, 2016 |  BC Innovations  |  Targets & Mechanisms

Making sense of sensors

Two new pathways are emerging as viable options for harnessing nucleic acid sensors in immuno-oncology, offering an alternative to the toll-like receptors (TLRs) that paved the way. By activating STING or RIG-I, researchers are expanding...
07:00 , May 12, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Mice with knockout of interferon-related genes as models of Zika infection

Disease models TECHNOLOGY: Transgenics and knockouts Two mouse models with knockout of interferon-related genes could be useful for screening therapies to treat Zika infection. In mice with knockout of interferon regulatory factor 3 (IRF3), IRF5 and IRF7,...
07:00 , Aug 18, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Interferon-betab (IFNB; IFN-b); interferon- aalpha/ beta b receptor 1 (IFNAR1); TANK-binding...
07:00 , Sep 23, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Interferon regulatory factor 7 (IRF7) A study in rats and in humans identified an IRF7-driven...