BC Innovations | May 12, 2016
Distillery Techniques

Techniques: Mice with knockout of interferon-related genes as models of Zika infection

Disease models TECHNOLOGY: Transgenics and knockouts Two mouse models with knockout of interferon-related genes could be useful for screening therapies to treat Zika infection. In mice with knockout of interferon regulatory factor 3 (IRF3) , IRF5...
BC Innovations | Sep 17, 2015
Distillery Therapeutics

Therapeutics: Interferon regulatory factor 5 (IRF5); chemokine CXC motif ligand 1 (CXCL1; GRO; MGSA)

Inflammation INDICATION: Inflammation Mouse studies suggest inhibiting IRF5 could help treat inflammatory diseases. In a mouse model of antigen-induced arthritis, IRF5 knockout decreased knee swelling, synovial membrane thickening, synovial levels of neutrophil-recruiting CXCL1 and the...
BC Innovations | May 28, 2015
Distillery Therapeutics

Therapeutics: Interferon regulatory factor 5 (IRF5)

Endocrine/metabolic disease INDICATION: Obesity Mouse studies suggest inhibiting IRF5 could help treat obesity. Levels of IRF5 mRNA and protein were higher in myeloid cells in the visceral adipose tissue of obese individuals than in those...
Items per page:
1 - 3 of 3