22:16 , Jun 1, 2017 |  BC Innovations  |  Translation in Brief

Odd couples

A Stanford University team has built synthetic ligands that force cytokine receptor subunits into unnatural pairings, and showed the "synthekines" were able to trigger new patterns of signaling and cytokine secretion in blood cells. The...
01:21 , Jan 12, 2017 |  BC Innovations  |  Translation in Brief

Give me a break

In 2013, two groups introduced the paradoxical and, at the time, controversial hypothesis that blocking antiviral cytokine signals can help clear chronic infections by reinvigorating T cells exhausted from non-stop inflammation. One of those groups...
00:50 , Jan 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: HIV/AIDS Mouse studies suggest inhibiting IFNAR2 or IFNAR1 could help treat HIV1 infection. In a humanized mouse model of chronic HIV infection, an anti-IFNAR2 mAb decreased plasma viral load and levels of exhaustion markers...
07:00 , Jun 18, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Infectious disease Influenza Interferon a/b receptor (IFNAR1; IFNAR2; IFN-r); chemokine CXC motif ligand 1 (CXCL1); CXCL2 Studies in mice suggest that targeting IFN-r could help...
07:00 , May 14, 2001 |  BC Week In Review  |  Company News

University of Missouri other research news

University researchers published in the Proceedings of the National Academy of Sciences that bovine kidney cells were completely protected from vesicular stomatitis virus by the extracellular domain (R2E) of interferon alpha receptor 2 ( IFNAR2...