08:00 , Feb 17, 2011 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Sortase-catalyzed modification to increase stability of therapeutic proteins In vitro and mouse studies suggest that sortase-mediated pegylation and circularization...
08:00 , Feb 17, 2011 |  BC Innovations  |  Tools & Techniques

Engineering protein stability

Two American teams have proposed distinct strategies to improve the stability of recombinant proteins. The techniques could be used to increase the manufacturing yield, shelf life and potentially the duration of efficacy of biologics, including...
07:00 , May 21, 2001 |  BC Week In Review  |  Clinical News

Atragen tretinoin: Phase I data; Phase II

In a 17-patient U.S. Phase I trial of Atragen in combination with interferon alpha, 2 of 16 evaluable patients who received 15 mg/m 2 dosages of Atragen showed partial remission in bone and lung metastases...
07:00 , May 30, 2000 |  BC Week In Review  |  Clinical News

Atragen tretinoin: Phase I/II

In ARNX’s Phase I/II dose escalation trial of Atragen in combination with interferon alpha, 2 of 3 patients had partial remissions. The trial was started using doses of 90 mg/m 2 Atragen every other day...
07:00 , May 30, 2000 |  BC Week In Review  |  Clinical News

Atragen tretinoin: Phase I/II

In ARNX's Phase I/II dose escalation trial of Atragen in combination with interferon alpha, 2 of 3 patients had partial remissions. The trial was started using doses of 90 mg/m2 Atragen every other day plus...