BC Innovations | Dec 11, 2018
Distillery Therapeutics


INDICATION: Inflammatory disease Cell culture studies suggest combined inhibition of BRD4 and HDAC could help treat type I interferon-driven diseases. In fibroblasts from patients deficient in the type I interferon regulators ISG15 or USP18, a...
BC Innovations | Jun 30, 2016
Translation in Brief

Inverted immunity

A cohort of interferon-stimulated gene 15 ( ISG15 )-deficient adolescents has revealed the protein has opposite roles in the viral immunities of mice and humans, and produced data suggesting inhibitors could provide a broad therapeutic strategy...
BC Innovations | Jun 23, 2016
Distillery Therapeutics

Therapeutics: Interferon-stimulated gene 15 (ISG15); interferon induced protein with tetratricopeptide repeats 1 (IFIT1)

Infectious disease INDICATION: Viral infection Patient sample studies suggest inhibiting ISG15 could help treat viral infections. In vitro, stimulation with interferon α (IFNα) and IFNβ of fibroblasts from ISG15-deficient volunteers induced more persistent expression of...
BC Innovations | Mar 5, 2015
Distillery Therapeutics

Therapeutics: Interferon-stimulated gene 15 (ISG15); ubiquitin specific peptidase 18 (USP18; ISG43)

Infectious disease INDICATION: Viral infection Mouse studies suggest inhibiting the protease activity of USP18 could help treat viral infections. USP18 downregulates ISG15 , which plays a role in interferon (IFN)-mediated responses to viral infection, but complete...
BC Week In Review | Nov 21, 2011
Company News

Advaxis, University of Pennsylvania deal

The university granted Advaxis an exclusive license to interferon-stimulated gene 15 (ISG15) for use in Advaxis' Listeria monocytogenes Listeriolysin O (Lm-LLO) based immunotherapies. Advaxis said the IP could be used to treat breast and other...
BioCentury | Apr 23, 2007
Tools & Techniques

Upstaging Velcade

When Millennium Pharmaceuticals Inc. began working on the first proteasome inhibitor to reach the market, Velcade bortezomib, one of the potential issues was that the presence of proteasomes in all cells and the proteasome's broad...
BC Extra | Jan 20, 2007
Clinical News

Researchers identify IFN-stimulated antiviral

Researchers from Washington University and colleagues reported in the Proceedings of the National Academy of Sciences that interferon-stimulated gene 15 (ISG15) functions as a critical antiviral molecule against both DNA and RNA viruses. Mice that...
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