BioCentury | Oct 10, 2013
Distillery Therapeutics

Indication: Cancer

...and contact information Cancer Cancer Integrin-linked kinase (ILK); parvin-b (PARVB) Mouse and cell culture studies suggest inhibiting ILK...
...help prevent tumor metastasis. In murine mammary carcinoma cell lines, small hairpin RNA knockdown of Ilk...
...no knockdown. In mice injected with metastatic mammary carcinoma cells, shRNA knockdown of Parvb or Ilk...
BioCentury | Feb 23, 2012
Distillery Therapeutics

Indication: Cancer

...a5 (CD49e); integrin b1 (CD29); integrin-linked kinase (ILK); NF-kB Patient sample and mouse studies suggest inhibiting the integrin/ILK/NF-kB...
...and ILK all correlated with decreased survival. In a mouse model of IGFBP2-driven glioma, inhibiting Ilk...
...the incidence of high-grade gliomas compared with no inhibition. Next steps could include evaluating integrin, ILK...
BioCentury | Jan 23, 2012
Emerging Company Profile

Dermira: Success is skin deep

...small molecule selective sebum biosynthesis inhibitor to treat acne; DRM 02, a topical small molecule integrin-linked kinase (ILK)...
BioCentury | Aug 25, 2011
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Integrin-linked kinase (ILK) In vitro and...
...a propanamide derivative could help treat prostate cancer. In a library screen, the compound inhibited ILK...
BioCentury | Jan 4, 2010
Finance

Great(er) expectations

...efficiently raised a lot of capital. As they have financed, there are fewer of their ilk...
BioCentury | Jun 5, 2008
Distillery Therapeutics

This Week in Therapeutics

...stroke; neurodegenerative diseases Brain-derived neurotrophic factor (BDNF); neurotrophic tyrosine kinase, receptor, type 2 (TrkB; NTRK2); integrin-linked kinase (ILK)...
...E-CM, using a fragment of the BDNF receptor TrkB, eliminated the protective effect. Knockdown of ILK...
BioCentury | Jan 29, 2007
Product Development

Optical focus

For years, the ophthalmic space was more or less moribund as far as biotech was concerned, populated mainly by old-line companies peddling old-line treatments. But both the aging of the population and the rise in...
BioCentury | Jun 21, 2004
Strategy

Not just skin deep

...of I25 IUDR radiopharmaceutical Locally advanced solid tumors Preclin ATRX Atrigel risperidone Antipsychotic Preclin ATRX ILK...
BioCentury | Apr 10, 2000
Politics, Policy & Law

Too much Congress is bad for your health

...stuff probably doesn't work - it is utterly indefensible that these herbals, nutraceuticals and their ilk...
BioCentury | Mar 20, 2000
Company News

Kinetek other research news

...Kinetek researchers and colleagues published in the Proceedings of the National Academy of Sciences that ILK...
...in cells containing mutations in PTEN , a tumor suppressor gene, and that inhibition of ILK...
...PTEN mutations and induces cell cycle arrest and apoptosis. The researchers suggested that small molecule ILK...
Items per page:
1 - 10 of 14