16:13 , Feb 20, 2019 |  BC Innovations  |  Distillery Therapeutics

Hepatic

INDICATION: Liver disease Mouse studies suggest INSIG1 could help treat non-alcoholic fatty liver disease (NAFLD). In a AMPK-knockout mouse model of NAFLD, INSIG1 encoded in an adenoviral vector decreased liver triglyceride levels, a marker of...
08:00 , Dec 17, 2009 |  BC Innovations  |  Targets & Mechanisms

Deprogramming stroke

Canadian researchers have taken an entirely new tack on preventing neurotoxicity in acute ischemic stroke by targeting a pathway previously linked to cholesterol metabolism. 1 The University of British Columbia team suggests that a set...
08:00 , Dec 17, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Stroke Sterol regulatory element binding transcription factor 1 (SREBF1; SREBP1); insulin induced gene 1 (INSIG1) Studies in cell culture and in rats suggest that antagonizing...