BioCentury | Jul 21, 2016
Distillery Therapeutics

Therapeutics: Mucolipin 1 (TRPML1; MCOLN1); inositol polyphosphate-5-phosphatase f (INPP5F)

...caused by mutations in INPP5F . In primary human kidney proximal tubule cells, siRNA targeting INPP5F...
...number of autophagosomes and decreased autophagosome-lysosomal fusion, autophagic flux and TRPML1 activity compared with normal INPP5F...
...TRPML1 activators in animal models of Lowe syndrome. TARGET/MARKER/PATHWAY: Mucolipin 1 (TRPML1; MCOLN1 ); inositol polyphosphate-5-phosphatase f (INPP5F...
BioCentury | May 21, 2015
Distillery Therapeutics

Therapeutics: Inositol polyphosphate-4-phosphatase type II (INPP4B); phosphatase and tensin homolog deleted on chromosome ten (PTEN; MMAC1; TEP1)

Cancer INDICATION: Thyroid cancer Mouse and human sample studies suggest agonizing INPP4B could help treat PTEN-deficient thyroid cancer. INPP4B levels were lower in thyroid tissues samples from thyroid cancer patients than in samples from control...
BioCentury | Apr 9, 2015
Distillery Therapeutics

Therapeutics: Inositol polyphosphate-5-phosphatase D (INPP5D); spleen tyrosine kinase (SYK)

Cancer INDICATION: Acute lymphoblastic leukemia (ALL) In vitro and mouse studies suggest hyperactivating SYK could help treat tyrosine kinase inhibitor (TKI)-resistant ALL. Philadelphia chromosome-positive (Ph+) ALL cells from patients expressed higher levels of receptors that...
BioCentury | May 27, 2010
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Nerve damage; neurology; stroke Inositol polyphosphate-4-phosphatase type I (INPP4A) A study in mice suggests that increasing INPP4A expression could help prevent excitotoxicity-induced nerve damage that...
BioCentury | Feb 5, 2009
Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/ marker/ pathway Summary Licensing status Publication and contact information Infectious disease Bacterial infection Inositol polyphosphate-5-phosphatase (INPP5D; SHIP) Studies in mice suggest that activating SHIP could be useful for preventing...
BioCentury | Mar 5, 2007
Tools & Techniques

Expanding the HDAC envelope

...HDAC2 works in the heart in part by activating expression of inositol polyphosphate-5-phosphate f ( INPP5F...
...now found that inhibition of HDAC2 causes constitutive activation of GSK-3 beta through activation of INPP5F...
...in large animals and humans and also plan to further test the specific role of INPP5F...
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