13:20 , May 9, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Neuropathy...
08:00 , Mar 5, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Inhibitor of κ light polypeptide gene enhancer in B-cells kinase complex-associated protein (IKBKAP)

Neurology INDICATION: Neuropathy In vitro studies identified a compound that could help treat familial dysautonomia, which is often caused by an IKBKAP mutation that results in skipping of exon 20 and consequently misspliced protein. A...
08:00 , Dec 12, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Disease models

This week in techniques Approach Summary Licensing status Publication and contact information Disease models Mouse model of familial dysautonomia (FD) with neural crest lineage-specific knockout of inhibitor of k-light polypeptide gene enhancer in B-cells kinase...
07:00 , Sep 12, 2013 |  BC Innovations  |  Targets & Mechanisms

All in the family

PTEN induced putative kinase 1 is a tantalizing player in familial forms of Parkinson's disease, in which it is inactivated by mutation, but thus far the kinase has been a no-fly zone for drug development...
08:00 , Jan 10, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Inhibitor of k-light polypeptide gene enhancer in B cells kinase complex-associated protein (IKBKAP); adrenergic receptor a2 (ADRA2) A study in...
08:00 , Jan 10, 2013 |  BC Innovations  |  Tools & Techniques

Scaling up iPS cells

A Memorial Sloan-Kettering Cancer Center team has conducted one of the first large-scale screens of a small molecule library using patient-derived induced pluripotent stem cells. 1 The approach was applied to neuronal cells derived from...