23:48 , Aug 8, 2018 |  BC Innovations  |  Distillery Therapeutics

Hepatic

INDICATION: Liver disease Mouse studies suggest inhibiting IKKα or its activator MAP3K14 could help treat liver disease. In a partial hepatectomy mouse model of liver injury, hepatocyte-specific knockout of MAP3K14 or IKKα increased hepatocyte proliferation and...
22:54 , Apr 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Lung cancer Patient sample, cell culture, and mouse studies suggest inhibiting IKKα could help treat KRAS-mutant lung adenocarcinoma. In patient samples, levels of IKKα were higher in tumors than in adjacent normal lung tissue. In...
22:33 , Nov 21, 2017 |  BC Extra  |  Preclinical News

New tool for degradation of endogenous proteins

In a study published in Cell, researchers at Medical Research Council Laboratory of Molecular Biology (MRC LMB) and colleagues describe a new protein degradation technique called Trim-Away that harnesses a naturally occurring ubiquitinating protein and...