23:48 , Aug 8, 2018 |  BC Innovations  |  Distillery Therapeutics

Hepatic

INDICATION: Liver disease Mouse studies suggest inhibiting IKKα or its activator MAP3K14 could help treat liver disease. In a partial hepatectomy mouse model of liver injury, hepatocyte-specific knockout of MAP3K14 or IKKα increased hepatocyte proliferation...
22:54 , Apr 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Lung cancer Patient sample, cell culture, and mouse studies suggest inhibiting IKKα could help treat KRAS-mutant lung adenocarcinoma. In patient samples, levels of IKKα were higher in tumors than in adjacent normal lung tissue....
22:33 , Nov 21, 2017 |  BC Extra  |  Preclinical News

New tool for degradation of endogenous proteins

In a study published in Cell , researchers at Medical Research Council Laboratory of Molecular Biology (MRC LMB) and colleagues describe a new protein degradation technique called Trim-Away that harnesses a naturally occurring ubiquitinating protein...
07:00 , Apr 23, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Inhibitor of κ light gene enhancer in B cells kinase α (IKKα; IKBKA; IKK1; CHUK; NFKBIKA); IKKβ (IKBKB; IKK2; NRKBIKB)

Cancer INDICATION: Cancer In vitro and mouse studies suggest the natural product (+)-ainsliadimer A could help treat cancer. In vitro, (+)-ainsliadimer A covalently bound the cysteine 46 residue of IKKα and IKKβ (Ki = 30...
07:00 , Mar 12, 2015 |  BC Innovations  |  Targets & Mechanisms

TBK1 and beyond

Biogen Idec Inc. 's partnership with Columbia University and the HudsonAlpha Institute for Biotechnology has yielded a new target in ALS - TBK1 - that provides a link between autophagy, neuroinflammation and the pathology of...
07:00 , Mar 25, 2010 |  BC Innovations  |  Cover Story

A B cell burden in prostate cancer

Although castration therapies such as androgen ablation are standard prostate cancer treatments, many patients develop resistance in 12-18 months. 1 Now, researchers from the University of California, San Diego and Scripps Florida have found that...
07:00 , Apr 23, 2007 |  BioCentury  |  Tools & Techniques

Likely kinase cancer genes

Likely kinase cancer genes Rank Gene Protein 1 TTN Titin 2 BRAF V-raf murine sarcoma viral oncogene homolog B1 3 ATM Ataxia telangiectasia mutated 4 TAF1L TAF1-like RNA polymerase II 5 ERN1 Endoplasmic reticulum to...
07:00 , Apr 23, 2007 |  BioCentury  |  Tools & Techniques

High probability pathways

High probability pathways Pathway Genes in pathway (A) Pathway components [Ranking] (A) [5] Fibroblast growth factor (FGF) signaling MAP2K4; FGFR4; FGFR1; MAPK14; MAPK8; MAPK9; FGFR3; MAP3K6; MAP3K2; MAPK11; PRKCB1; RAF1; PRKCA; PRKCH; MAPK13; AKT3; PRKCE;...
07:00 , Apr 12, 1999 |  BC Week In Review  |  Company News

Signal Pharmaceuticals other research news

Signal researchers and colleagues, along with separate groups at the University of California (San Diego, Calif.) and Hyogo College of Medicine (Hyogo, Japan) published in Science additional data on the mechanisms that activate the pro-inflammatory...
07:00 , Jul 28, 1997 |  BC Week In Review  |  Company News

Tularik other research news

Tularik researchers published in Cell the identification of a protein kinase that responds to inflammatory stimuli and activates the NF-kB transcription factor. The protein, conserved helix-loop-helix ubiquitous kinase (CHUK), had been previously identified but its...