14:22 , May 14, 2019 |  BC Innovations  |  Distillery Therapeutics

Pyridopyrimidine-based inhibitors of the IK-SMU1 interaction for influenza

DISEASE CATEGORY: Infectious disease INDICATION: Influenza virus Cell culture studies identified two pyridopyrimidine-based inhibitors of the IK cytokine-SMU1 interaction that could help treat influenza A virus infection. In silico screening of a small molecule library...
16:17 , Oct 4, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Zika virus Mouse studies suggest a vaccine based on Zika NS1, Env and prM could help prevent Zika infection. The vaccine consists of the three viral genes encoded in an attenuated recombinant vesicular stomatitis...
16:09 , Aug 16, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Zika virus Cell culture studies suggest promoting PARP-12 expression could help treat Zika infection. In human lung epithelial cell line-based stability assays of Zika virus non-structural protein NS1 (Zika NS1) or NS3, PARP-12 encoded...
21:00 , Apr 12, 2018 |  BC Innovations  |  Translation in Brief

Viral variant vaccine

A team from Duke-NUS Medical School rapidly developed a live-attenuated Zika vaccine candidate by exploiting genetic errors to identify a strain with high viremia and reduced propagation. The approach could speed development of live vaccines...
17:54 , Nov 1, 2017 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: October 2017

New Therapeutic Targets and Biomarkers: October 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during October 2017. Therapeutic targets are defined as any protein, gene or other...
13:53 , Oct 31, 2017 |  BC Innovations  |  Distillery Techniques

Assays and screens

TECHNOLOGY: Diagnostic assays An immunochromatography-based assay that detects viral NS1 proteins could aid the rapid differential diagnosis of Zika infection and dengue fever caused by serotypes DENV1-4. The assay utilizes six immunochromatography dipsticks that each...
14:07 , Aug 23, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Zika virus Mouse studies suggest a live-attenuated vaccine encoding loss-of-function mutations in Zika NS1 could help treat Zika viral infection. In pregnant mice with Zika infection, the vaccine decreased Zika viral levels in the...
21:34 , Aug 3, 2017 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: July 2017

New Therapeutic Targets and Biomarkers: July 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during July 2017. Therapeutic targets are defined as any protein, gene or other...
23:49 , Jul 19, 2017 |  BC Extra  |  Preclinical News

Vaccines protect against fetal Zika transmission

In a paper published in Cell , researchers showed that two different vaccines restricted Zika virus transmission from a pregnant mother to the fetus and protected against placental damage and fetal demise. The team tested...
01:26 , Jan 6, 2017 |  BC Innovations  |  Product R&D

Viral ambitions

  Meissa Vaccines Inc. is translating studies from an Emory University team into a pair of vaccine platforms to protect specific at-risk subpopulations from infections by two otherwise innocuous viruses, RSV and the common cold....