BC Innovations | Apr 17, 2018
Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Mouse studies suggest mAbs against influenza A virus neuraminidase subtypes N1 or N2 could help prevent or treat influenza. In mouse challenge models of lethal H3N2 and H1N1 influenza infection, pre-challenge treatment...
BC Innovations | Mar 21, 2013
Targets & Mechanisms

Trapping influenza neuraminidase

Researchers at The University of British Columbia have used a mechanism-based approach to design irreversible inhibitors of influenza virus neuraminidase that could have activity against flu strains resistant to marketed inhibitors of the target. 1...
BC Innovations | Dec 20, 2012
Cover Story

Translating mRNA vaccines

A collaboration between CureVac GmbH and the Friedrich Loeffler Institute has produced in vivo evidence that an mRNA-based vaccine can prevent influenza A infection. 1 The results provide proof of concept for the company's vaccine...
BC Innovations | Dec 20, 2012
Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms mRNA vaccines to prevent influenza A infection Vaccination with a mixture of protamine-complexed mRNAs could help prevent influenza A infection. A...
BC Innovations | Dec 20, 2012
Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms mRNA vaccines to prevent influenza A infection Vaccination with a mixture of protamine-complexed mRNAs could help prevent influenza A infection. A...
BC Innovations | Oct 20, 2011
Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Influenza virus Influenza A virus neuraminidase (NA) In vitro studies identified two phosphonate-based compounds that could help treat drug-resistant influenza...
BC Innovations | Jan 14, 2010
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Influenza virus Influenza A virus neuraminidase An in vitro study identified diarylheptanoid neuraminidase inhibitors that could be useful for treating influenza virus infection. In...
BC Innovations | Jun 25, 2009
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Influenza virus Influenza A virus neuraminidase Studies in cell culture suggest that porphyrin-zanamivir conjugates are photodynamic therapeutics for influenza A infection. In vitro, conjugates...
BC Innovations | May 7, 2009
Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Influenza virus Influenza A virus hemagglutinin (HA); Influenza A virus neuraminidase (NA); Influenza A virus matrix protein M2 (M2); Influenza...
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