18:58 , Apr 5, 2019 |  BC Week In Review  |  Clinical News

NIH begins universal flu vaccine trial

NIH has begun dosing subjects in a Phase I trial of its universal flu vaccine, with data readouts expected in early 2020. The open-label, U.S. trial assessing safety and production of anti-influenza virus antibodies is...
14:24 , Mar 19, 2019 |  BC Innovations  |  Distillery Therapeutics

Small molecule HA inhibitor for treating H1, H5 flu infections

DISEASE CATEGORY: Infectious disease INDICATION: Influenza virus Cell culture and mouse studies identified a small molecule HA inhibitor that could help treat H1 and H5 influenza A infections. In vitro screening of a compound library...
20:53 , Mar 8, 2019 |  BC Extra  |  Preclinical News

Janssen, Scripps discover small molecule for flu

Janssen and Scripps have generated an oral compound for treating flu that inhibits the HA protein on influenza H1 and H5 strains. Recent studies have led to the development of broadly neutralizing antibodies (bNAbs) that...
21:11 , Feb 28, 2019 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Mouse studies suggest an inactivated influenza virus vaccine expressing monoglycosylated HA could help prevent infection by multiple influenza A virus strains. The vaccine consists of inactivated H1N1 influenza virus particles modified to...
13:52 , Jan 29, 2019 |  BC Innovations  |  Distillery Techniques

Drug platforms; other

TECHNOLOGY: Antibody scaffolds; computational models A method of optimizing antibodies for broad activity against different viral strains could be used to generate antibodies to treat infections by influenza and other multi-strain viruses. The method is...
20:47 , Nov 6, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Cell culture and mouse studies suggest a quadspecific antibody against influenza A and influenza B HA epitopes could help prevent infection by multiple strains of influenza A and influenza B viruses. The...
22:37 , Nov 1, 2018 |  BC Extra  |  Preclinical News

Llama antibodies could provide universal flu protection

Researchers at Janssen Pharmaceuticals Inc. and the Scripps Research Institute have created a prophylactic universal flu therapy by combining four llama antibodies into a single protein. Most flu vaccines stimulate the generation of antibodies against...
20:24 , Oct 31, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer; infectious disease

INDICATION: Cancer; melanoma; cervical cancer; influenza virus Mouse and monkey studies suggest simvastatin could be used as an adjuvant to boost the efficacy of cancer and influenza vaccines. In mice, immunization with the antigen ovalbumin...
17:57 , Oct 25, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Coronavirus; influenza virus; HIV/AIDS; Ebola Cell culture and rat studies identified lipopeptide-based inhibitors of MERS-CoV S protein, Ebola virus glycoprotein and HIV env that could help treat Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola...
23:28 , Oct 3, 2018 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Mouse studies suggest a vaccine based on multiple conformations of an HA1 epitope could help prevent influenza A infection. Crystallographic analyses of HA1 from four strains of influenza A virus identified five...