07:00 , Apr 30, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Inducible T cell kinase (ITK)

Inflammation INDICATION: Asthma In vitro and mouse studies suggest tetrahydrindazole-based ITK inhibitors could help treat asthma and other inflammatory diseases. Optimization of a previously identified tetrahydrindazole-based ITK inhibitor (Ki = 0.7 nM) identified a lead...
07:00 , Jul 24, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammatory disease Inducible T cell kinase (ITK) In vitro and in vivo studies have identified a tetrahydroindazole-based ITK inhibitor called GNE-9822 that could help treat...
08:00 , Jan 9, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Autoimmune disease Inducible T cell kinase (ITK) Mouse studies suggest inhibiting ITK could help treat autoimmune diseases. In mice, double knockout of Ctla-4 (Cd152)...
08:00 , Nov 5, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Asthma Inducible T cell kinase (ITK); IL-17 Studies in cell culture and mice suggest that antagonizing ITK could help treat allergic asthma. In response to...
07:00 , Apr 9, 2009 |  BC Innovations  |  Distillery Therapeutics

This week in therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Infectious disease Epstein-Barr virus (EBV) Inducible T cell kinase (ITK); IL-2 Studies in patient samples and in cell culture identified an...
07:00 , May 15, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease HIV/AIDS IL-2-inducible T cell kinase (ITK) A cell culture study suggests that inhibiting ITK could prevent HIV infection. Human CD4+...
07:00 , May 15, 2008 |  BC Innovations  |  Targets & Mechanisms

ITK: TKO for HIV

HIV's resistance to antiretrovirals has led researchers to target host proteins upon which the virus depends for survival. Compounds targeting these proteins are harder for HIV to resist but are potentially more toxic to the...
07:00 , Apr 23, 2007 |  BioCentury  |  Tools & Techniques

Likely kinase cancer genes

Likely kinase cancer genes Rank Gene Protein 1 TTN Titin 2 BRAF V-raf murine sarcoma viral oncogene homolog B1 3 ATM Ataxia telangiectasia mutated 4 TAF1L TAF1-like RNA polymerase II 5 ERN1 Endoplasmic reticulum to...
07:00 , Apr 23, 2007 |  BioCentury  |  Tools & Techniques

Ranking the kinase kingdom

After four years of work, researchers at the Wellcome Trust Sanger Institute and colleagues have elucidated the prevalence and signature of somatic mutations in human protein kinases. The findings, recently reported in Nature , have...