BioCentury | Dec 21, 2020
Translation in Brief

Reversible control of CAR expression; plus an inflammation-reducing mAb, two intranasal COVID-19 treatments and more

...inflammation in mice and hamsters. TARGETSAIOLOS (IKZF3) – IKAROS family zinc finger 3 IL-36R (ILRL2) – Interleukin-1 (IL-1) receptor-like 2 SARS-CoV-2...
...protein Danielle Golovin Revlimid, lenalidomide (cdc 501, CC-5013) Theravectys S.A. Novartis Institutes for BioMedical Research Regeneron Pharmaceuticals Inc. Eureka Therapeutics Inc. Institut Pasteur CD19 Interleukin-1 (IL-1) receptor-like 2 (IL-36R) (ILRL2) covid-19 cov19sci cov19sci...
BioCentury | Oct 15, 2020
Product Development

Oct. 14 Quick Takes: FDA approves first Ebola therapy; plus Vertex tumbles after hours on AAT discontinuation

...decitabine or both. AnaptysBio gains on pustular psoriasis dataAnaptysBio Inc. (NASDAQ:ANAB) gained 15% to $20.37 after IL-36R...
...in response to FDA’s proposal to withdraw its approval of Makena hydroxyprogesterone to prevent premature births.TargetsIL-36R (ILRL2...
BioCentury | Jan 30, 2020
Distillery Therapeutics

IL1RL1 in Treg cells as a lung cancer target

DISEASE CATEGORY: Cancer INDICATION: Lung cancer Inhibiting IL1RL1, which signals in response to IL-33 binding, in Treg cells could treat lung cancer. In single-cell RNA sequencing analyses of CD4 + T cells from the lymph...
BioCentury | Nov 8, 2019
Clinical News

AnaptysBio left with slimmer pipeline after eczema candidate fails Phase IIb

...$25.98 (72%) to $10.18 Friday. The company's only other wholly-owned clinical assets are ANB019, an IL-36R...
...Interleukin-13 receptor α 1; IL-4R (IL-4RA; CD124) - Interleukin-4 receptor; IL-33 (NF-HEV) - Interleukin-33; IL-36R (ILRL2...
BioCentury | Mar 8, 2019
Clinical News

Boehringer reports first data for IL-36R inhibitor in rare type of psoriasis

...patients experiencing an acute moderate-to-severe flare of the disease. BI 655130 is a mAb against IL-36R...
...ulcerative colitis, atopic dermatitis, Crohn’s disease and palmoplantar pustulosis. AnaptysBio Inc. (NASDAQ:ANAB) is developing an anti-IL-36R...
...Phase II testing for generalized pustular psoriasis and palmoplantar pustulosis. Brian Moy, Assistant Editor BI 655130 Boehringer Ingelheim GmbH Interleukin-1 (IL-1) receptor-like 2 (IL-36R) (ILRL2) Psoriasis American...
BioCentury | Mar 7, 2019
Company News

Moderna announces pipeline updates in first financial results

In its first quarterly financial results as a public company, Moderna announced its first rare disease mRNA program is heading to the clinic. Moderna Inc. (NASDAQ:MRNA) said Wednesday that it has submitted an IND for...
BioCentury | Feb 5, 2019
Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer; melanoma; cancer Mouse studies suggest an mRNA immunotherapy based on IL-36γ, IL-23 and OX40L could help treat colorectal cancer, melanoma and other cancers, including those resistant to checkpoint inhibitors. The therapy consists...
BioCentury | Jan 31, 2019
Preclinical News

Moderna's triplet mRNA therapy treats checkpoint inhibitor-resistant tumors in mice

Moderna Inc. (NASDAQ:MRNA) published preclinical data Wednesday showing a triple mRNA combination product has efficacy against solid tumors, including those resistant to checkpoint inhibitors. The company's mRNA-2752 contains mRNAs encoding IL-23, IL-36γ and OX40L encapsulated...
BioCentury | Oct 31, 2018
Company News

GSK cuts some respiratory targets, keeps others in play

GlaxoSmithKline plc (LSE:GSK; NYSE:GSK) cut three respiratory programs against targets largely ignored by the rest of the industry after all three failed to meet efficacy targets in Phase II trials. The pharma disclosed the pruning...
BioCentury | Jan 23, 2018
Distillery Therapeutics

Dermatology

...genes. In a mouse model of S. aureus infection-induced dermatitis, systemic knockout of IL-1 receptor, IL-36R...
...nine genes. Also in the model, systemic knockout of IL-1 receptor plus a mAb targeting IL-36R...
...Myeloid differentiation primary response gene 88 (MYD88); interleukin-1 receptor (IL-1 receptor); interleukin-1 receptor-like 2 (IL-36R; ILRL2...
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