BioCentury | Nov 7, 2020
Emerging Company Profile

IgGenix: antibody engineering for food allergies

...isn’t to eliminate or change natural allergen-reactive IgE antibodies, but to outcompete them for allergen binding. “IgE...
...B cell clones expressing allergen-specific IgE antibodies. It has isolated “a large number of human IgE...
...Phase I. According to Croote, working from IgE antibodies has an advantage over using an IgG base. “IgE...
BioCentury | Oct 28, 2020
Product Development

Data Byte: FOLR1 pipeline for cancer

...are no active trials of farletuzumab on ClinicalTrials.gov.TARGETSFOLR1 (FR-alpha; FOLR) – Folate receptor 1 Danielle Golovin farletuzumab (MORAb-003) MOv18 IgE mirvetuximab...
BioCentury | Aug 31, 2020
Deals

Takeout premium shows Nestlé’s faith in Aimmune peanut product, despite launch slowed by COVID

...egg allergy. The company also expects to submit an IND in 1Q21 for AIMab7195, an anti-IgE...
BioCentury | Jul 31, 2020
Product Development

U.K. locks down access to recombinant protein vaccine via GSK, Sanofi deal, its fourth for COVID-19

...IFNα and IFNλ. They also associated severe disease to type-2 immune markers including eosinophils and IgE...
BioCentury | Jun 5, 2020
Emerging Company Profile

Epsilogen: co-opting IgE antibodies against cancer

...that each IgE brings a cell-killing immune cell with it to the target antigen. These IgE-immune...
...and into the tissues in search of the IgE’s antigen target. While the mechanism for IgE...
...said. Wilson believes Epsilogen’s latest Phase I data for lead program MOv18 IgE, an anti-FOLR1 IgE...
BioCentury | Apr 16, 2020
Product Development

April 15 Quick Takes: TScan, Novartis team up on TCR therapies and a first for UroGen; plus Aligos, Leo, Madrigal, Merck

...Co. Ltd. to develop and commercialize FB825, a candidate targeting the CεmX domain of membrane-bound IgE...
...Co. Ltd., a JV between Biogen Inc. (NASDAQ:BIIB) and Samsung BioLogics Co. Ltd. (KOSDAQ:207940). Targets IgE...
BioCentury | Mar 14, 2020
Emerging Company Profile

Indapta harnesses natural NK cell subset to create allogeneic cancer therapy

...Undisclosed Targets CD16 (FCGR3) - Fc gamma receptor III FCER1G (FCεR1γ) - Fc fragment of IgE...
BioCentury | Feb 6, 2020
Finance

Feb. 5 Financial Quick Takes: Aimmune gets $200M Nestlé investment; plus Vineti, MaaT, Kezar, Ziopharm, Ikarovec

...outstanding common shares. Also on Wednesday, Aimmune licensed exclusive, worldwide rights to a mAb against IgE...
BioCentury | Aug 23, 2019
Distillery Techniques

Fecal levels of bacterial genes, metabolite in neonates as childhood allergic disease biomarker

...disease including asthma and atopy. Administration of the metabolite exacerbated pulmonary inflammation and raised serum IgE...
BioCentury | Jul 11, 2019
Distillery Therapeutics

Treating asthma, allergic diseases with mAbs against crystallized proteins

...formation of LGALS10 crystals in vitro . One of the antibodies prevented bronchial hyperresponsiveness and IgE...
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