BioCentury | Nov 7, 2020
Product Development

Amgen’s adaptive solution to lupus

...targeting T and B cells through inhibiting ICOSLG...
...TNF superfamily member 13bICOSLG (B7-H2; B7RP1) – Inducible T cell co-stimulator ligand Lauren...
BioCentury | Oct 9, 2020
Translation in Brief

Philogen immunocytokine for glioma; plus Nordic's radiotherapy, Beth Israel Deaconness, Molecular Partners and Alpine

...Zurich (ETHZ) Philogen S.p.A. Novartis AG Indiana University Medical University of South Carolina Alpine Immune Sciences Inc. Nordic Nanovector ASA Molecular Partners AG Inducible T cell co-stimulator ligand (ICOSLG) (B7-H2) (B7RP1) CD28 Inducible...
BioCentury | Jun 19, 2020
Deals

In second innovative deal this month, AbbVie gains option to Alpine’s ‘first-in-class’ lupus program

...Cytotoxic T-lymphocyte associated protein 4 ICOS - Inducible T cell co-stimulator ICOSL (B7-H2; B7RP1) - Inducible T cell co-stimulator ligand...
BioCentury | Jan 3, 2019
Distillery Therapeutics

Transplant

...INDICATION: Organ transplant rejection Mouse studies suggest inhibiting CXCL13, CD40L and ICOSLG, which play roles in...
...with a control IgG. Also in the model, an anti-CD40L mAb in combination with an anti-ICOSLG...
...TARGET/MARKER/PATHWAY: Chemokine CXC motif ligand 13 (CXCL13); CD40 ligand (CD40L; CD40LG; CD154); inducible T cell co-stimulator ligand (ICOSLG; B7-H2; B7RP1...
BioCentury | Aug 24, 2018
Targets & Mechanisms

Computing checkpoints

...in its Ig domain with ligands in the B7 family, such as PD-L1, VISTA and ICOSLG...
...Kenilworth, N.J. Targets DNAM-1 (CD226) ICOS - Inducible T cell co-stimulator ICOSLG (B7-H2; B7RP1) - Inducible T cell co-stimulator ligand...
BioCentury | Aug 11, 2017
Strategy

The flip-side of immunotherapy

...LSE:AZN; NYSE:AZN) MEDI0700 Lupus ICOSLG (B7-H2; B7RP1) - Inducible T cell co-stimulator ligand Bispecific mAb targeting BLyS (BAFF) and ICOSLG...
BioCentury | Jun 15, 2017
Tools & Techniques

Breaking the barrier

...soloMERs to the eye for ophthalmic autoimmune and inflammatory conditions. It has ELN/21 , an ICOSLG...
...tat protein HRAS - v-Ha-ras Harvey rat sarcoma viral oncogene homolog ICOSLG (B7-H2; B7RP1) - Inducible T cell co-stimulator ligand...
BioCentury | Aug 1, 2016
Strategy

Check and mate

...several lineages of effector T cells, including Th1, Th2 and Th17. Engagement of ICOS by ICOSLG...
BioCentury | May 26, 2011
Distillery Therapeutics

Indication: Autoimmune disease

...in vitro screen identified B7-H2 as a ligand of CD28. In stimulated T cells, a B7-H2-blocking...
...T cell proliferation compared with a control antibody. Next steps include studying the role of B7-H2...
BioCentury | May 26, 2011
Distillery Therapeutics

Indication: Autoimmune disease

...in vitro screen identified B7-H2 as a ligand of CD28. In stimulated T cells, a B7-H2-blocking...
...T cell proliferation compared with a control antibody. Next steps include studying the role of B7-H2...
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