BioCentury | Dec 4, 2020
Finance

Dec. 3 Quick Takes: Israeli digital health firm closes $170M fund; plus BioAge, newco Rubedo, Portal Innovations, OliX

...Kiwoom Investment, NH Investment & Securities, Aju IB Investment and Widwin Investment.   TARGETSHIF-PH (EGLN) – Hypoxia-inducible factor...
BioCentury | Sep 4, 2020
Product Development

Akebia’s prospects dim after safety readout in non-dialysis CKD patients

...LSE:AZN; NYSE:AZN) market roxadustat in China.TARGETSHIF-PH – Hypoxia-inducible factor...
...MT-6548, akb-6548) Evrenzo, roxadustat (ASP1517, FG-4592) Akebia Therapeutics Inc. FibroGen Inc. Hypoxia-inducible factor...
BioCentury | Jun 30, 2020
Regulation

Data Bytes: Drug approvals in Japan

...only other approval for the mAb against IL-6R is in Canada. Targets HIF-PH (EGLN) - Hypoxia-inducible factor...
BioCentury | May 28, 2020
Distillery Therapeutics

Reducing kidney damage in lupus by targeting HIF1A

...survival. Next steps include mechanistic studies of HIF1A blockade as therapeutic strategy for lupus. TARGET/MARKER/PATHWAY: Hypoxia-inducible factor...
...CONTACT: Joseph Craft, Yale School of Medicine, New Haven, Conn. email: joseph.craft@yale.edu Claire Quang Yale School of Medicine Hypoxia-inducible factor...
BioCentury | May 6, 2020
Product Development

May 5 Quick Takes: Data propel Adverum, TG, Akebia stocks; plus Tolmar, SRI-Exscientia, Sino-GeoVax

...were not disclosed. Targets GNRH (GNRH1) - Gonadotropin releasing hormone 1 Target2 HIF-PH (EGLN) - Hypoxia-inducible factor...
BioCentury | Feb 5, 2020
Product Development

Leaner GSK ups R&D investments in immunology, genetics

...constant exchange rates. Adjusted EPS for 2019 was 123.9p, up 1%. Targets HIF-PH (EGLN) - Hypoxia-inducible factor...
BioCentury | Jan 1, 2020
Company News

Fewer FDA approvals in 2019, but a basket of firsts

...conductance regulator HER2 (EGFR2; ErbB2; neu) - Epidermal growth factor receptor 2 HIF-PH (EGLN) - Hypoxia-inducible factor...
BioCentury | Dec 24, 2019
Company News

Regulatory roundup: BioMarin poised to have first U.S., EU hemophilia gene therapy; plus Allergan, Eisai, FibroGen, ViiV and Vero

...circulate blood through an artificial lung. Targets: CGRP - Calcitonin gene-related peptide; HIF-PH (EGLN) - Hypoxia-inducible factor...
...E2006) roxadustat (ASP1517, FG-4592) BioMarin Pharmaceutical Inc. Allergan plc Eisai Co. Ltd. ViiV Healthcare Ltd. FibroGen Inc. Factor VIII Calcitonin gene-related peptide (CGRP) receptor Hypoxia-inducible factor...
BioCentury | Nov 19, 2019

Combining Arava with HIF1A inhibition to treat RA

...Sanofi (Euronext:SAN; NASDAQ:SNY) markers Arava, a DHODH inhibitor that blocks pyrimidine synthesis, for RA. TARGET/MARKER/PATHWAY: Hypoxia-inducible factor...
...doi:10.1038/s41467-019-12163-z CONTACT: Ge Zhang, Hong Kong Baptist University, Hong Kong, China email: zhangge@hkbu.edu.hk Claire Quang Dihydroorotate dehydrogenase (DHODH) Hypoxia-inducible factor...
BioCentury | Oct 8, 2019
Tools & Techniques

Nobel Prize for cell response to oxygen, a two-sided therapeutic target

...diseases. William Kaelin, Peter Ratcliffe and Gregg Semenza share the award for their discoveries of hypoxia-inducible factor...
...Aryl hydrocarbon receptor nuclear translocator; EGLN (HIF-PH) - Hypoxia-inducible factor prolyl hydroxylase; HIF1A (HIF1-α) - Hypoxia-inducible factor...
...Therapeutics Inc. University of Oxford Francis Crick Institute Johns Hopkins University Dana-Farber Cancer Institute Harvard Medical School Hypoxia-inducible factor 1 alpha (HIF1A) (HIF1-alpha) Hypoxia-inducible factor...
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