BioCentury | Jun 20, 2018
Distillery Techniques

Drug platforms

...cell line, the cocktail plus the CRISPR-Cas12a system designed to introduce mutations into hypoxanthine phosphoribosyltransferase 1 (HPRT1; HGPRT...
...Planck Institute for Evolutionary Anthropology CRISPR from Prevotella and Francisella 1 (Cas12a) (Cpf1) CRISPR-associated protein 9 (Cas9) DNA methyltransferase Hypoxanthine phosphoribosyltransferase 1 (HPRT1) (HGPRT)...
BioCentury | Jan 12, 2018
Product R&D

Avidity’s affinity for muscle

...an undisclosed antibody. The company has data showing the compound knocked down the housekeeping gene HPRT1...
...Pharmaceuticals Inc. (NASDAQ:IONS), Carlsbad, Calif. Targets GALNT14 (GalNAc-T14) - Polypeptide N-acetylgalactosaminyltransferase 14 HPRT1 (HGPRT) - Hypoxanthine phosphoribosyltransferase 1...
BioCentury | Sep 4, 2014
Distillery Techniques

Technology: Disease models

...the calcium calmodulin-dependent protein kinase II (CAMK2) promoter was knocked in to the hypoxanthine phosphoribosyltransferase 1 (Hprt1; Hgprt...
BioCentury | Apr 30, 2012
Company News

Cellectis, Precision BioSciences genomics news

Precision filed suit in the U.S. District Court for the Eastern District of North Carolina alleging that Cellectis is infringing on U.S. Patent No. 8,163,514 through the making, using, selling or importing into the U.S....
BioCentury | Apr 2, 2012
Company News

Cellectis, Precision BioSciences genomics news

Precision filed suit in the U.S. District Court for the Eastern District of North Carolina alleging that Cellectis is infringing on U.S. Patent Nos. 8,143,016 and 8,143,015 through the making, using, selling or importing into...
BioCentury | Mar 12, 2012
Company News

Cellectis, Precision BioSciences genomics news

Precision filed suit in the U.S. District Court for the Eastern District of North Carolina alleging that Cellectis is infringing on U.S. Patent No. 8,129,134 through the sale of meganucleases targeting the HIV-1 genome, the...
BioCentury | Jul 16, 2009
Distillery Therapeutics

Indication: Infectious disease

...Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Malaria Plasmodium falciparum hypoxanthine phosphoribosyltransferase 1 (Hprt1; Hgprt...
...that could help treat malaria. In vitro, several ANPs selectively inhibited the P. falciparum enzyme Hgprt...
BioCentury | Feb 17, 2003
Company News

University of Wisconsin other research news

...electroporation methodology to apply homologous recombination to knock out the gene encoding hypoxanthine phosphoribosyl-transferase-1 ( HPRT1...
BioCentury | Aug 26, 1996
Company News

University of North Carolina other research news

University researchers published a method to choose exactly where to insert genes among a mouse's genes. This method of targeted transgenesis relies on homologous recombination in embryonic stem (ES) cells of mice, so that the...
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