BioCentury | Mar 30, 2021
Finance

March 30 Quick Takes: BioNTech anticipates €9.8B year; plus Immune-Onc, Amgen-Rodeo, Stuart, Bond

...available modulators of prostaglandin pathways associated with tissue regeneration and repair; its lead program targets HPGD...
...the GI tract; its lead compound is in Phase I testing for hereditary hemochromatosis.TARGETSHPGD (15-PGDH) – Hydroxyprostaglandin dehydrogenase 15 NAD BC...
BioCentury | Dec 12, 2020
Translation in Brief

Fecal transplant improves checkpoint inhibitor response in Phase I; plus Secarna’s antitumor antisense oligos, a blood-based mRNA test for Alzheimer’s and more

...on HPGD inhibition.TARGETSCD39 (ENTPD1) – Ectonucleoside triphosphate diphosphohydrolase 1 CTLA-4 (CTLA4; CD152) – Cytotoxic T-lymphocyte associated protein 4 HPGD...
...– Ectonucleoside triphosphate diphosphohydrolase 1 CTLA-4 (CTLA4; CD152) – Cytotoxic T-lymphocyte associated protein 4 HPGD (15-PGDH) – Hydroxyprostaglandin dehydrogenase 15 NAD MTDH...
...GmbH Princeton University Firebrand Therapeutics Inc. Stanford University Tel Aviv University Molecular Stethoscope Inc. National Institutes of Health Metadherin (MTDH) (AEG1) Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD) (15-PGDH) Prostaglandin...
BioCentury | Aug 8, 2019
Tools & Techniques

Checkpoint inhibitors are bringing oncolytic viruses back into the spotlight

...immunity and to deliver the toll-like receptor adaptor molecule 1 (TICAM1; TRIF) and hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH...
BioCentury | Sep 13, 2017
Emerging Company Profile

Not PGE2's first Rodeo

...higher" than the desired average therapeutic level. Rodeo is instead targeting hydroxyprostaglandin dehydrogenase 15 NAD ( HPGD ; 15-PGDH...
...well. COMPANY PROFILE Rodeo Therapeutics Corp. Seattle, Washington Technology: Inhibitor of hydroxyprostaglandin dehydrogenase 15 NAD ( HPGD ; 15-PGDH...
...the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration." Science (2015) Virginia Li, Staff Writer Rodeo Therapeutics Corp. Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD) (15-PGDH) Prostaglandin...
BioCentury | Jul 25, 2017
Financial News

Accelerator leads Rodeo's series A round

...Alice Chen told BioCentury that Rodeo's lead candidate, an inhibitor of hydroxyprostaglandin dehydrogenase 15 NAD ( HPGD ; 15-PGDH...
...Ready, a professor at University of Texas Southwestern Medical Center. Chris Lieu Accelerator Life Science Partners Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD) (15-PGDH) Rodeo...
BioCentury | Jul 9, 2015
Distillery Therapeutics

Therapeutics: Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH)

...Transplantation INDICATION: Tissue replacement Mouse studies suggest inhibiting HPGD could help regenerate tissues after transplantation or...
...injury. In vitro high throughput screening of small molecule library identified a compound that inhibited HPGD...
...of the compound and testing HPGD inhibition in other tissue regeneration models. TARGET/MARKER/PATHWAY: Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH...
BioCentury | May 15, 2014
Distillery Techniques

Technology: Markers

...Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH) expression as a biomarker of aspirin-associated decrease in colorectal cancer risk Measuring HPGD...
...had high HPGD expression in the colonic mucosa but not in subjects who had low HPGD...
...expression. Next steps include carrying out a prospective clinical trial to determine whether levels of HPGD...
BioCentury | Sep 6, 2012
Targets & Mechanisms

Passenger mutations take the wheel

...elongation factor 2 Protein synthesis PHF5A PHD finger protein 5A Spliceosome-mediated mRNA splicing HPGD (15-PGHD) Hydroxyprostaglandin dehydrogenase 15 NAD...
BioCentury | May 28, 2009
Distillery Therapeutics

Indication: Cancer

...Cancer Colon cancer Hydroxoprostaglandin dehydrogenase 15-(NAD) (15-PGDH) Studies in mice suggest that low levels of 15-PGDH...
...celecoxib adjunct therapy during colon cancer treatment. In a mouse model of chemically-induced colon adenoma, 15-PGDH...
...15-PGDH's potential as a predictive marker in a validation trial and identifying compounds that increase 15-PGDH...
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