21:20 , Sep 13, 2017 |  BioCentury  |  Emerging Company Profile

Not PGE2's first Rodeo

Rodeo Therapeutics Corp. is boosting prostaglandin E2 production within cells rather than delivering it systemically to promote tissue regeneration without the side effects that have dogged the molecule in the past. Tissues up-regulate prostaglandin E2...
13:28 , Jul 25, 2017 |  BC Extra  |  Financial News

Accelerator leads Rodeo's series A round

Newly launched Rodeo Therapeutics Corp. (Seattle, Wash.) raised $5.9 million in a series A round led by Accelerator Corp. (Seattle, Wash.). Also participating were AbbVie Ventures, Alexandria Venture Investments, ARCH Venture, Eli Lilly and Co....
07:00 , Jul 9, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH)

Transplantation INDICATION: Tissue replacement Mouse studies suggest inhibiting HPGD could help regenerate tissues after transplantation or injury. In vitro high throughput screening of small molecule library identified a compound that inhibited HPGD with a Ki...
07:00 , May 15, 2014 |  BC Innovations  |  Distillery Techniques

Technology: Markers

Approach Summary Licensing status Publication and contact information Markers Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH) expression as a biomarker of aspirin-associated decrease in colorectal cancer risk Measuring HPGD expression could help predict whether regular aspirin...
07:00 , Sep 6, 2012 |  BC Innovations  |  Targets & Mechanisms

Passenger mutations take the wheel

Two research groups have independently shown that targeting genes carrying passenger mutations blocked growth of cancer cells and improved survival in mouse models. 1,2 Although precise therapeutic windows for such a strategy remain to be...
07:00 , May 28, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Colon cancer Hydroxoprostaglandin dehydrogenase 15-(NAD) (15-PGDH) Studies in mice suggest that low levels of 15-PGDH could help predict resistance to...