BioCentury | Aug 8, 2019
Tools & Techniques

Checkpoint inhibitors are bringing oncolytic viruses back into the spotlight

...immunity and to deliver the toll-like receptor adaptor molecule 1 (TICAM1; TRIF) and hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH...
BioCentury | Sep 13, 2017
Emerging Company Profile

Not PGE2's first Rodeo

...higher" than the desired average therapeutic level. Rodeo is instead targeting hydroxyprostaglandin dehydrogenase 15 NAD ( HPGD ; 15-PGDH...
...well. COMPANY PROFILE Rodeo Therapeutics Corp. Seattle, Washington Technology: Inhibitor of hydroxyprostaglandin dehydrogenase 15 NAD ( HPGD ; 15-PGDH...
...the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration." Science (2015) Virginia Li, Staff Writer Rodeo Therapeutics Corp. Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD) (15-PGDH) Prostaglandin...
BioCentury | Jul 25, 2017
Financial News

Accelerator leads Rodeo's series A round

...Alice Chen told BioCentury that Rodeo's lead candidate, an inhibitor of hydroxyprostaglandin dehydrogenase 15 NAD ( HPGD ; 15-PGDH...
...and Joseph Ready, a professor at University of Texas Southwestern Medical Center. Chris Lieu Accelerator Corp. Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD) (15-PGDH) Rodeo...
BioCentury | Jul 9, 2015
Distillery Therapeutics

Therapeutics: Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH)

...Transplantation INDICATION: Tissue replacement Mouse studies suggest inhibiting HPGD could help regenerate tissues after transplantation or...
...injury. In vitro high throughput screening of small molecule library identified a compound that inhibited HPGD...
...of the compound and testing HPGD inhibition in other tissue regeneration models. TARGET/MARKER/PATHWAY: Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH...
BioCentury | May 15, 2014
Distillery Techniques

Technology: Markers

...Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD; 15-PGDH) expression as a biomarker of aspirin-associated decrease in colorectal cancer risk Measuring HPGD...
...had high HPGD expression in the colonic mucosa but not in subjects who had low HPGD...
...expression. Next steps include carrying out a prospective clinical trial to determine whether levels of HPGD...
BioCentury | Sep 6, 2012
Targets & Mechanisms

Passenger mutations take the wheel

...elongation factor 2 Protein synthesis PHF5A PHD finger protein 5A Spliceosome-mediated mRNA splicing HPGD (15-PGHD) Hydroxyprostaglandin dehydrogenase 15 NAD...
BioCentury | May 28, 2009
Distillery Therapeutics

Indication: Cancer

...Cancer Colon cancer Hydroxoprostaglandin dehydrogenase 15-(NAD) (15-PGDH) Studies in mice suggest that low levels of 15-PGDH...
...celecoxib adjunct therapy during colon cancer treatment. In a mouse model of chemically-induced colon adenoma, 15-PGDH...
...15-PGDH's potential as a predictive marker in a validation trial and identifying compounds that increase 15-PGDH...
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