07:00 , Sep 28, 2009 |  BC Week In Review  |  Clinical News

Alnylam, Medtronic preclinical data

In a non-human primate model of HD, ALN-HTT delivered to the CNS via Medtronic's implantable pump infusion system achieved broad distribution of the siRNA targeting huntingtin mRNA . Direct delivery of ALN-HTT to the CNS...
07:00 , Apr 17, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Huntington's disease (HD) Huntingtin A study in mice suggests that microRNA might be safer than and equally efficacious to small hairpin...
07:00 , Apr 17, 2008 |  BC Innovations  |  Targets & Mechanisms

shRNA: Solving the Subtle

A report published in the Proceedings of the National Academy of Sciences illustrates how subtle structural differences between two types of RNAs-artificial small hairpin RNA and endogenous microRNA-may help explain the difference between shRNA having...