BioCentury | Sep 28, 2009
Clinical News

Alnylam, Medtronic preclinical data

...siRNA targeting huntingtin mRNA . Direct delivery of ALN-HTT to the CNS resulted in silencing of huntingtin mRNA...
BioCentury | Apr 17, 2008
Distillery Therapeutics

This Week in Therapeutics

...small hairpin RNA for treating HD. In HD transgenic mouse models, brain-delivered miRNA constructs targeting huntingtin mRNA...
...extended to test long-term safety. Next steps include assessing the neurological and behavioral effects of huntingtin mRNA...
BioCentury | Apr 17, 2008
Targets & Mechanisms

shRNA: Solving the Subtle

...35 shRNA constructs that target different parts of the huntingtin gene, looking for reductions in huntingtin mRNA...
...candidates were injected into the brains of transgenic mice with HD. Although all three reduced huntingtin mRNA...
...compared with the original shRNA experiments while still achieving similar drops in the levels of huntingtin mRNA...
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