20:22 , May 1, 2019 |  BC Extra  |  Preclinical News

May 1 Preclinical Quick Takes: MD Anderson, Sana, Sigilon

MD Anderson findings could make radiation possible for pancreatic cancer  Researchers at University of Texas MD Anderson Cancer Center reported findings suggesting that HIF-PH inhibition could help prevent radiation-induced GI injury, the main factor that...
13:07 , Jan 17, 2019 |  BC Innovations  |  Emerging Company Profile

Zelluna’s solid TCR plans

Zelluna Immunotherapy A/S is using a portfolio of HLA class II-restrictive TCRs to develop autologous cell therapies that could unleash a broader immune attack on solid tumors than other TCR-based cell therapies in development. CEO...
14:01 , Jan 3, 2019 |  BC Innovations  |  Translation in Brief

Neo opportunities in glioblastoma

Phase I results from a consortium led by BioNTech AG and Immatics Biotechnologies GmbH convinced both companies that personalized immunotherapies can turn on T cell activity in glioblastoma, an immunologically "cold" cancer. The study is...
13:42 , Jan 3, 2019 |  BC Innovations  |  Distillery Techniques

Assays and screens; other

TECHNOLOGY: Cellular assays; computational models A computational method to predict HLA peptide presentation could help identify neoantigens for cancer immunotherapy. The deep learning model was trained on a data set to identify the relationships between...
07:01 , Dec 18, 2018 |  BC Extra  |  Tools & Techniques

Gritstone showcases mass spec-based neoantigen discovery platform

Gritstone Oncology Inc. (NASDAQ:GRTS) unveiled the inner workings of its mass spectrometry-based neoantigen identification platform, EDGE, in a Nature Biotechnology study published Monday. Results from the paper suggest building a machine-learning algorithm based on human...
13:29 , Dec 5, 2018 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: 3-D models Patient-derived placenta-like organoids could be used to study preeclampsia and other pregnancy-related disorders and screen therapies to treat them. The organoids are generated by culturing human placenta-derived trophoblasts in culture media with...
23:00 , Nov 12, 2018 |  BC Extra  |  Preclinical News

Sequencing-based method identifies neoantigen-specific TCRs

In a Nature Biotechnology paper , researchers described a method to identify TCRs that bind to specific neoantigens, which could enable efficient and inexpensive production of personalized T cell therapies. The high-throughput technique, developed by...
18:19 , Oct 18, 2018 |  BC Innovations  |  Distillery Techniques

Assays and screens; biomarkers

TECHNOLOGY: Cellular assays, diagnostic assays; plasma markers Circulating CD4 + T cells specific for full-length C-peptide could be used for early diagnosis of Type I diabetes. In peripheral blood samples from patients with recent-onset Type...
22:23 , Oct 11, 2018 |  BC Innovations  |  Translation in Brief

Cancer antigens from RNA edits

A team from Immatics Biotechnologies GmbH and University of Texas MD Anderson Cancer Center has shown that cancer antigens generated via post-transcriptional RNA editing could further broaden the target space for immunotherapies. The study ,...
17:13 , Aug 23, 2018 |  BC Innovations  |  Translation in Brief

The self-destructing pancreas

A pair of independent papers from researchers from Washington University School of Medicine in St. Louis and Institut National de la Santé et de la Recherche Médicale (INSERM) illustrate how pancreatic β cells may contribute...