BioCentury | Nov 25, 2020
Product Development

Data Byte: a snapshot of the clinical cutaneous T cell lymphoma pipeline

...significant adverse events. Synthetic hypericin, the active ingredient in SGX301, accumulates in T cells and targets Hsp90...
...therapy are expected by year-end. TARGETSCCR4 (CD194) – CC chemokine receptor 4HDAC – Histone deacetylaseHsp90Heat shock protein 90 IL-2...
BioCentury | Oct 21, 2020
Product Development

UCSF’s virus-host protein interaction maps ID targets for COVID-19, future coronaviruses

...TOMM70, preventing the mitochondrial protein’s interaction with Hsp90.Other...
BioCentury | Aug 8, 2020
Translation in Brief

Cocrystal’s COVID-19 antivirals; plus a portable breast cancer diagnostic, Tarveda mini-drug conjugate for solid tumors, and more

...PIK3CA-driving solid tumors Tarveda Therapeutics Inc. showed in Molecular Cancer Therapeutics proof-of-concept data for an Hsp90-binding...
...Estrogen receptor HER2 (EGFR2; ErbB2; neu) - Epidermal growth factor receptor 2 Hsp90 - Heat shock protein 90...
...Mpro) (SARS-CoV main protease) SARS-CoV-2 3C-like protease (SARS-CoV-2 3CLpro) (SARS-CoV-2 NSP5) (SARS-CoV-2 Mpro) (SARS-CoV-2 main protease) Heat shock protein 90 (Hsp90) Phosphoinositide...
BioCentury | Nov 21, 2019
Tools & Techniques

Measuring real-time PK/PD by monitoring aberrant chaperone activity

...pathology-associated cellular stress, the protein-protein interaction network core -- which contains co-chaperones and chaperones including Hsp90...
...probe. Since PU-H71 takes days to dissociate from epichaperome-associated Hsp90 vs. minutes for other cellular Hsp90...
...HspA8 (HSC70) - Heat shock 70 kDa protein Inhua Muijrers-Chen, Associate Editor Memorial Sloan Kettering Cancer Center Heat shock protein 90 (Hsp90) PK/PD...
BioCentury | Oct 17, 2019

Small molecule disruption of Hsp90-CDC37 interaction for colorectal cancer

...Hsp90-CDC37 interaction followed by optimization of the top hit yielded N-(mesitylsulfonyl)-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4 yl)amino)phenyl) glycine, which bound Hsp90...
...compound also decreased tumor growth in a xenograft mouse model of the disease. TARGET/MARKER/PATHWAY: Heat shock protein 90 (Hsp90...
...of Medicine, Shanghai, China email: jian.zhang@sjtu.edu.cn Claire Quang China Pharmaceutical University Shanghai Jiao Tong University School of Medicine Heat shock protein 90 (Hsp90...
BioCentury | Sep 30, 2019
Company News

Vertex seeks small molecules for RNA in deal with Ribometrix

...HD drug discovery assays. Vertex published in 2014 a Journal of Medicinal Chemistry paper describing Hsp90...
...additional funding from existing investors, the Dementia Discovery Fund and Illumina Ventures. Targets: Hsp90 - Heat shock protein 90...
BioCentury | May 8, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: April 2019

...EBV gL; EBV BKRF2) Fungal infection Fungal heat shock protein 90 (Fungal Hsp90) Preclinical studies suggest inhibiting fungal Hsp90...
BioCentury | Apr 12, 2019
Emerging Company Profile

Bright Angel: New hope against fungal resistance

...about fungal Hsp90 to human Hsp90 crystal structures to guide discovery chemistry. Jaikaran said the Hsp90...
...Ont. Targets Fungal DHODH - Fungal dihydroorotate dehydrogenase Fungal Hsp90 - Fungal heat shock protein 90 Hsp90 - Heat shock protein 90 Sandi...
...Fungal heat shock protein 90 Hsp90 - Heat shock protein 90 Sandi Wong, Staff Writer Bright Angel Therapeutics Inc. Fungal dihydroorotate dehydrogenase (Fungal DHODH) Heat shock protein 90 (Hsp90) Fungal...
BioCentury | Jan 16, 2019
Distillery Therapeutics

Cancer

...INDICATION: Brain cancer Cell culture and mouse studies identified a naphthalenone-based Hsp90 inhibitor that could help...
...Hsp90, in Phase I through Phase II testing for a variety of cancers. TARGET/MARKER/PATHWAY: Heat shock protein 90 (Hsp90...
...A&M University, Houston, Texas email: yzhou@ibt.tamhsc.edu Claire Quang Shandong University Texas A&M University University of Texas Health Science Center Heat shock protein 90 (Hsp90) Brain...
BioCentury | Oct 25, 2018
Distillery Therapeutics

Autoimmune disease

...testing the inhibitor in additional models of UC. Samus Therapeutics Inc. has PU-H71, a purine-based pan-Hsp90...
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