...significant adverse events. Synthetic hypericin, the active ingredient in SGX301, accumulates in T cells and targets Hsp90...
...therapy are expected by year-end. TARGETSCCR4 (CD194) – CC chemokine receptor 4HDAC – Histone deacetylaseHsp90 – Heat shock protein 90 IL-2...

...TOMM70, preventing the mitochondrial protein’s interaction with Hsp90.Other...

...PIK3CA-driving solid tumors Tarveda Therapeutics Inc. showed in Molecular Cancer Therapeutics proof-of-concept data for an Hsp90-binding...
...Estrogen receptor HER2 (EGFR2; ErbB2; neu) - Epidermal growth factor receptor 2 Hsp90 - Heat shock protein 90...
...Mpro) (SARS-CoV main protease) SARS-CoV-2 3C-like protease (SARS-CoV-2 3CLpro) (SARS-CoV-2 NSP5) (SARS-CoV-2 Mpro) (SARS-CoV-2 main protease) Heat shock protein 90 (Hsp90) Phosphoinositide...

...pathology-associated cellular stress, the protein-protein interaction network core -- which contains co-chaperones and chaperones including Hsp90...
...probe. Since PU-H71 takes days to dissociate from epichaperome-associated Hsp90 vs. minutes for other cellular Hsp90...
...HspA8 (HSC70) - Heat shock 70 kDa protein Inhua Muijrers-Chen, Associate Editor Memorial Sloan Kettering Cancer Center Heat shock protein 90 (Hsp90) PK/PD...

...Hsp90-CDC37 interaction followed by optimization of the top hit yielded N-(mesitylsulfonyl)-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4 yl)amino)phenyl) glycine, which bound Hsp90...
...compound also decreased tumor growth in a xenograft mouse model of the disease. TARGET/MARKER/PATHWAY: Heat shock protein 90 (Hsp90...
...of Medicine, Shanghai, China email: jian.zhang@sjtu.edu.cn Claire Quang China Pharmaceutical University Shanghai Jiao Tong University School of Medicine Heat shock protein 90 (Hsp90...

...HD drug discovery assays. Vertex published in 2014 a Journal of Medicinal Chemistry paper describing Hsp90...
...additional funding from existing investors, the Dementia Discovery Fund and Illumina Ventures. Targets: Hsp90 - Heat shock protein 90...

...EBV gL; EBV BKRF2) Fungal infection Fungal heat shock protein 90 (Fungal Hsp90) Preclinical studies suggest inhibiting fungal Hsp90...

...about fungal Hsp90 to human Hsp90 crystal structures to guide discovery chemistry. Jaikaran said the Hsp90...
...Ont. Targets Fungal DHODH - Fungal dihydroorotate dehydrogenase Fungal Hsp90 - Fungal heat shock protein 90 Hsp90 - Heat shock protein 90 Sandi...
...Fungal heat shock protein 90 Hsp90 - Heat shock protein 90 Sandi Wong, Staff Writer Bright Angel Therapeutics Inc. Fungal dihydroorotate dehydrogenase (Fungal DHODH) Heat shock protein 90 (Hsp90) Fungal...

...INDICATION: Brain cancer Cell culture and mouse studies identified a naphthalenone-based Hsp90 inhibitor that could help...
...Hsp90, in Phase I through Phase II testing for a variety of cancers. TARGET/MARKER/PATHWAY: Heat shock protein 90 (Hsp90...
...A&M University, Houston, Texas email: yzhou@ibt.tamhsc.edu Claire Quang Shandong University Texas A&M University University of Texas Health Science Center Heat shock protein 90 (Hsp90) Brain...

...testing the inhibitor in additional models of UC. Samus Therapeutics Inc. has PU-H71, a purine-based pan-Hsp90...