BioCentury | Nov 26, 2018
Distillery Techniques

Drug delivery

...construct loaded with an siRNA targeting heat shock 27 kDa protein 1 (HspB1; Hsp27) decreased HspB1...
...the targeting peptide. In a xenograft mouse model of prostate cancer, delivery of the tumor-targeting, HspB1...
...email: xiaoxuanliucpu@163.com CONTACT: Ling Peng, Aix-Marseille University, Marseille, France email: ling.peng@univ-amu.fr Jaime De Leon Aix-Marseille University China Pharmaceutical University Heat shock 27 kDa protein 1 (HspB1) (Hsp27) Integrin...
BioCentury | Apr 24, 2018
Distillery Therapeutics

Hematology

...INDICATION: Myeloproliferative disorder Patient sample and mouse studies suggest inhibiting Hsp27 could help treat myelofibrosis (MF...
...samples and circulating hematopoietic progenitor cells from patients with myeloproliferative neoplasm (MPN)-associated MF, levels of Hsp27...
...include identifying and testing Hsp27 inhibitors in models of MF. TARGET/MARKER/PATHWAY: Heat shock protein 27 (Hsp27...
BioCentury | Aug 24, 2017
Translation in Brief

Unclumping TDP-43

...and autophagy-mediated degradation. Overexpression of proteins downstream from HSF1 -- namely, heat shock protein 27 (Hsp27...
...Writer University of Zurich University of North Carolina at Chapel Hill DnaJ (Hsp40) homolog (DNAJ) Heat shock protein 27 (Hsp27) Heat...
BioCentury | Feb 8, 2017
Distillery Therapeutics

Neurology

INDICATION: Nerve damage Mouse studies suggest CRYAB could help treat peripheral nerve damage. In a mouse model of sciatic nerve damage, human CRYAB increased remyelination of the sciatic nerve and mechanical sensitivity and decreased gait...
BioCentury | Nov 10, 2016
Clinical News

Apatorsen: Final Ph II data

...Business: Cancer Molecular target: Heat shock protein 27 (Hsp27) Description: Second-generation antisense inhibitor of Hsp27...
...bladder cancer Endpoint: Overall survival (OS); safety, overall response rate (ORR), serum levels of Hsp27, Hsp27...
...Final Phase II data Milestone: NA Jaime De Leon apatorsen Ionis Pharmaceuticals Inc. OncoGenex Pharmaceuticals Inc. Heat shock protein 27 (Hsp27...
BioCentury | Sep 29, 2016
Distillery Techniques

Techniques: Panel of 12 hippocampal proteins to diagnose early stage Alzheimer's disease

...3 ( BAG3 , CAIR-1 ), heat shock 27 kDa protein 1 ( HspB1 ; Hsp27...
BioCentury | Apr 4, 2016
Finance

Restructuring watch

...the Phase II Spruce trial of the second-generation antisense inhibitor of heat shock protein 27 (Hsp27...
BioCentury | Feb 15, 2016
Company News

OncoGenex cancer news

...under an amended 2001 deal. Apatorsen, a second-generation antisense inhibitor of heat shock protein 27 (Hsp27...
BioCentury | Jan 25, 2016
Clinical News

Apatorsen: Phase II data

...Alimta. OncoGenex said a “potential PFS benefit” was observed in patients with high baseline serum Hsp27...
...target: Heat shock protein 27 (Hsp27) Description: Second-generation antisense inhibitor of heat shock protein 27 (Hsp27...
...NSCLC) Endpoint: Progression-free survival (PFS); overall survival (OS), tumor response rates, safety and effect on Hsp27...
BioCentury | Dec 21, 2015
Clinical News

Apatorsen: Phase II ongoing

...target: Heat shock protein 27 (Hsp27) Description: Second-generation antisense inhibitor of heat shock protein 27 (Hsp27...
...bladder cancer Endpoint: Overall survival (OS); safety, overall response rate (ORR) and serum levels of Hsp27...
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